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An ER protein scoots around to a site next to the plasma membrane (PM) to trigger calcium signaling, as shown by Wu et al. (page 803) and Luik et al. (page 815).
STIM1 (red) in the ER approaches Orai1 (green) in the plasma membrane upon loss of ER Ca2+ stores (bottom).
Cytoplasmic Ca2+ signals often come in two waves—a burst from the ER followed by a longer influx of extracellular Ca2+ through the PM's Ca2+ release–activated Ca2+ (CRAC) channels. The influx is triggered by the depletion of ER Ca2+ stores, which is sensed by a transmembrane ER Ca2+ sensor called STIM1. The new results reveal how STIM1 conveys the Ca2+ drop all the way from the ER to the PM.
Wu et al. show that Ca2+ store depletion causes STIM1 to relocate to ER...
The Rockefeller University Press
2006
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