Two chomosomes (red and green) mingle.

POMBO

Interphase human chromosomes show significant intermingling, say Miguel Branco and Ana Pombo (MRC Clinical Sciences Centre, London, UK). The idea is a counter to the most extreme view of chromosome territories.

Territories were so named based on microscopists' early observations: that individual chromosomes did not spread out over an entire nucleus. DNA labeling also indicated that nuclei had gaps between DNA, although it was not clear if these were between DNA of the same or different chromosomes. Still, this was enough to spark talk of an interchromatin domain separating territories. “In this model, it will always be right because two pieces of chromosome will never be in exactly the same place,” says Pombo. “The field couldn't move forward.”

She and Branco responded by labeling two different chromosomes in ultrathin slices and following up with EM for even higher...

The Rockefeller University Press
2006
The Rockefeller University Press
2006
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