Stat3 stabilizes microtubules

The STAT proteins are well-known as signaling proteins and transcription factors. But Ng et al. (page 245) report that Stat3 also functions in the cytoplasm, stabilizing microtubules by directly binding to and inhibiting the activity of a microtubule-destabilizing protein.

Stat3 functions in a variety of processes, including proliferation, survival, tumorigenesis, and migration. In each case, except migration, the protein works via transcriptional control of downstream effector proteins. How the protein controls migration is uncertain, though it is clear that cells lacking Stat3 do not migrate efficiently in vivo or in vitro.

Ng et al. found that Stat3 binds to stathmin, a protein that accelerates depolymerization of microtubules by binding to tubulin subunits. Stat3 bound stathmin via stathmin's tubulin-binding domain, blocking its depolymerizing activity.

Cultured cells lacking Stat3 showed a disordered microtubule network. However, expression...