A kinase-dead Ire1 (right) is resuscitated by 1NM-PP1.
Papa/AAAS
The new findings just add to the uniqueness of the Ire1 pathway, which responds to unfolded proteins. “This pathway is really a sort of duckbilled platypus,” says Papa. “There have been so many surprises.”
The response starts when unfolded proteins recruit chaperones away from Ire1; this is thought to expose a patch on Ire1 that mediates oligomerization. Transphosphorylation by Ire1 oligomers then somehow activates the RNase activity of Ire1, which excises an inhibitory intron from the HAC1...
The Rockefeller University Press
2003
The Rockefeller University Press
2003
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