β-COP (green) moves to help nuclear pore proteins (red) break down nuclear envelopes (right).

Ullman/Elsevier

Nuclear envelope breakdown requires vesiculation, based on work by Jin Liu, Katharine Ullman, and colleagues (University of Utah, Salt Lake City, UT).

Vesicles have previously been isolated from cells in which nuclear envelope breakdown has occurred, but it was always possible that the vesicles were formed as part of extract isolation rather than normal physiology. Now, the Utah team has found that the nuclear pore protein Nup153, COP1 coatomer proteins, and ARF GTPase are needed for nuclear envelope breakdown in frog egg extracts. COP1 components, which are better known for driving vesicle formation during intra-Golgi and Golgi-to-ER traffic, were also found to associate with Nup153 and to move from the Golgi to the nuclear periphery at the start of mitosis.

Initiation of nuclear envelope breakdown may be controlled by regulating...

The Rockefeller University Press
2003
The Rockefeller University Press
2003
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