Evolutionary perspective on innate immune recognition

Mushegian , Arcady; Medzhitov , Ruslan

doi:10.1083/jcb.200107040

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Review| November 26 2001

Evolutionary perspective on innate immune recognition

Arcady Mushegian,

Arcady Mushegian

1Stowers Institute for Medical Research, Kansas City, MO 64110

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Ruslan Medzhitov

2Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

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Author and Article Information

Arcady Mushegian

1Stowers Institute for Medical Research, Kansas City, MO 64110

Ruslan Medzhitov

2Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

Address correspondence to Ruslan M. Medzhitov, Yale University School of Medicine, Howard Hughes Medical Institute, 310 Cedar St., Rm. LH416, New Haven, CT 06520. Tel.: (203) 785-7541. Fax: (203) 737-1765. E-mail: [email protected]

The online version of this article contains supplemental material.

*

Abbreviations used in this paper: CTL, C-type lectin; GNBP, gram-negative binding protein; LPS, lipopolysaccharide; PAMP, pathogen-associated molecular pattern; TIR, Toll/interleukin-1 receptor; TLR, Toll-like receptor.

Received: July 10 2001

Revision Received: October 02 2001

Accepted: October 12 2001

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2001

J Cell Biol (2001) 155 (5): 705–710.

https://doi.org/10.1083/jcb.200107040

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