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Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels

Philipp A.M. Schmidpeter, Crina M. Nimigean

J Gen Physiol (2026) 158 (5): e202614025.

https://doi.org/10.1085/jgp.202614025

Published: 09 July 2026

View article titled, Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels

Journal Articles

Kinetic reconstruction of graded membrane excitability in Paramecium

Takashi Tominaga, Yoko Tominaga

J Gen Physiol (2026) 158 (5): e202613977.

https://doi.org/10.1085/jgp.202613977

Published: 07 July 2026

View article titled, Kinetic reconstruction of graded membrane excitability in Paramecium

Journal Articles

Evolution, hibernation, and inactivation of voltage-gated Na channels

John S. Willis

J Gen Physiol (2026) 158 (5): e202513923.

https://doi.org/10.1085/jgp.202513923

Published: 07 July 2026

View article titled, Evolution, hibernation, and inactivation of voltage-gated Na channels

Journal Articles

Conformational changes upon pore blocker removal reveal conductive states of TMEM16A

Christina A. Stephens, Frank V. Marcoline, Christian J. Peters, Michael Grabe

J Gen Physiol (2026) 158 (5): e202513961.

https://doi.org/10.1085/jgp.202513961

Published: 02 July 2026

View article titled, Conformational changes upon pore blocker removal reveal conductive states of TMEM16A

Includes: Supplementary data

Journal Articles

Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells

Yaw Akosah, Ioannis Azoidis, Dane D. Jensen, Paolo Bernardi, Evgeny V. Pavlov

J Gen Physiol (2026) 158 (5): e202613979.

https://doi.org/10.1085/jgp.202613979

Published: 30 June 2026

View article titled, Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells

Journal Articles

On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na⁺,K⁺-ATPase α1 subunit (ATP1A1)

Nicolas Colmano, Daniel Self, Hang N. Nielsen, Rikke Holm, Chai C. Gopalasingam, Ryota Fujimura, Kazuhiro Abe, Bente Vilsen, Sho T. Yano, Pablo Artigas

J Gen Physiol (2026) 158 (5): e202513959.

https://doi.org/10.1085/jgp.202513959

Published: 30 June 2026

View article titled, On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)

Includes: Supplementary data

Journal Articles

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in Na_V1.6 VSDIV

In Special Collection:

Voltage-Gated Na Channels 2026

Maxime Lammens, Jolien De Waele, Alain J. Labro, Filip Van Petegem, Frank Bosmans

J Gen Physiol (2026) 158 (5): e202614018.

https://doi.org/10.1085/jgp.202614018

Published: 29 June 2026

View article titled, Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

Journal Articles

Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity

Héctor Gaitán-Peñas, Salomé Llabrés, Marina Pedrola, Marc González-Subías, Jordi Juárez-Jiménez, Michael Pusch, Rodolfo Lavilla, Raúl Estévez

J Gen Physiol (2026) 158 (5): e202513953.

https://doi.org/10.1085/jgp.202513953

Published: 25 June 2026

View article titled, Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity

Includes: Supplementary data

Journal Articles

An epilepsy-associated K_V3.1 potassium channel variant acts via dominant-positive effect

Jerome Clatot, Hubert Monnerie, Axel Panzer, Konrad Platzer, Ethan M. Goldberg

J Gen Physiol (2026) 158 (5): e202513962.

https://doi.org/10.1085/jgp.202513962

Published: 25 June 2026

View article titled, An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect

Journal Articles

Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Samsudeen Ponissery Saidu, Alexander Kross, Michele Dibattista, Katharina Gaus, Johannes Reisert

J Gen Physiol (2026) 158 (4): e202513963.

https://doi.org/10.1085/jgp.202513963

Published: 23 June 2026

View article titled, Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky

J Gen Physiol (2026) 158 (4): e202413745.

https://doi.org/10.1085/jgp.202413745

Published: 18 June 2026

View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Includes: Supplementary data

Journal Articles

Will the real K_ATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue

Richard D. Rainbow, Richard Barrett-Jolley

J Gen Physiol (2026) 158 (4): e202614036.

https://doi.org/10.1085/jgp.202614036

Published: 15 June 2026

View article titled, Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue

Journal Articles

Unfurling the role of dysferlin’s C2A domain

Ben Short

J Gen Physiol (2026) 158 (4): e202614054.

https://doi.org/10.1085/jgp.202614054

Published: 12 June 2026

View article titled, Unfurling the role of dysferlin’s C2A domain

Journal Articles

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Shimon Schuldiner

J Gen Physiol (2026) 158 (4): e202614012.

https://doi.org/10.1085/jgp.202614012

Published: 08 June 2026

View article titled, Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Includes: Supplementary data

Journal Articles

A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Adam Feher, Geraldo Jorge Domingos, Martina Piga, Tihomir Tomašič, Nace Zidar, Zoltan Varga

J Gen Physiol (2026) 158 (4): e202513945.

https://doi.org/10.1085/jgp.202513945

Published: 28 May 2026

View article titled, A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Includes: Supplementary data

Journal Articles

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

In Special Collection:

Voltage-Gated Na Channels 2026

Yenisleidy Lorenzo-Ceballos, Pedro L. Martinez-Espinosa, Xiao-Ming Xia, Christopher J. Lingle

J Gen Physiol (2026) 158 (4): e202613985.

https://doi.org/10.1085/jgp.202613985

Published: 22 May 2026

View article titled, Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

Includes: Supplementary data

Journal Articles

Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Varun Verma, Ethan S. Lindgren, Marc H. Levin, Onur Cil, Lukmanee Tradtrantip, Rongshan Yan, Neel D. Pasricha, Alan S. Verkman

J Gen Physiol (2026) 158 (4): e202513958.

https://doi.org/10.1085/jgp.202513958

Published: 22 May 2026

View article titled, Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Journal Articles

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Magalí Colomer-Molera, Daniel Sastre, Antonio Felipe

J Gen Physiol (2026) 158 (4): e202513936.

https://doi.org/10.1085/jgp.202513936

Published: 20 May 2026

View article titled, Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Includes: Supplementary data

Journal Articles

Subunit composition of the K_ATP channels that modulate contractility of skeletal muscle during fatigue

Rosa Scala, Yuezhou Chen, Berk Mizrak, Gretchen A. Meyer, Colin G. Nichols

J Gen Physiol (2026) 158 (4): e202613986.

https://doi.org/10.1085/jgp.202613986

Published: 20 May 2026

View article titled, Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue

Journal Articles

Dysferlin’s C2A domain supports normal Ca²⁺ signaling and membrane repair in dysferlin-null myofibers

Valeriy Lukyanenko, Joaquin Muriel, Kassidy K. Banford, Thomas A. Kwiatkowski, Hannah R. Bulgart, Noah Weisleder, Robert J. Bloch

J Gen Physiol (2026) 158 (4): e202513844.

https://doi.org/10.1085/jgp.202513844

Published: 14 May 2026

View article titled, Dysferlin’s C2A domain supports normal Ca2+ signaling and membrane repair in dysferlin-null myofibers

Includes: Supplementary data

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Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels

Kinetic reconstruction of graded membrane excitability in Paramecium

Evolution, hibernation, and inactivation of voltage-gated Na channels

Conformational changes upon pore blocker removal reveal conductive states of TMEM16A

Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells

On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na⁺,K⁺-ATPase α1 subunit (ATP1A1)

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in Na_V1.6 VSDIV

Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity

An epilepsy-associated K_V3.1 potassium channel variant acts via dominant-positive effect

Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Will the real K_ATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue

Unfurling the role of dysferlin’s C2A domain

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Subunit composition of the K_ATP channels that modulate contractility of skeletal muscle during fatigue

Dysferlin’s C2A domain supports normal Ca²⁺ signaling and membrane repair in dysferlin-null myofibers

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