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Journal Articles

Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated ion channel, ELIC

Mark J. Arcario, Elizabeth J. Wu-Chen, Yuna Shim, Jérôme Hénin, Grace Brannigan, Wayland W.L. Cheng
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202513926.
https://doi.org/10.1085/jgp.202513926
Published: 27 August 2026
View article titled, Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated ion channel, ELIC
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Journal Articles

A hERG blocker facilitates K+ channel current by promoting pore opening while blocking

Steffen S. Docken, Matthew J. Marquis, Khoa Ngo, Yuumu Wada, Satomi Kita, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Igor Vorobyov, Timothy J. Lewis, Kazuharu Furutani, Jon T. Sack
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (6): e202614015.
https://doi.org/10.1085/jgp.202614015
Published: 27 August 2026
View article titled, A hERG blocker facilitates K+ channel current by promoting pore opening while blocking
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Journal Articles

Tunable AMPA receptor function via recurrent evolution of heterotetramers

Yuhong Wang, Alexander Edwards, Jelena Baranovic, Timothy Lynagh
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (6): e202614039.
https://doi.org/10.1085/jgp.202614039
Published: 27 August 2026
View article titled, Tunable AMPA receptor function via recurrent evolution of heterotetramers
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Includes: Supplementary data
Journal Articles

Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model

Arooj Shahid, Timothy S. McMillen, Samuel Daugherty, Anna E. Burns, Marloes van den Berg, Michael Regnier, Henk Granzier, Mei Methawasin
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (6): e202614028.
https://doi.org/10.1085/jgp.202614028
Published: 25 August 2026
View article titled, Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model
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Includes: Supplementary data
Journal Articles

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Ryan J. Farrell, S. Thomas Hennigan, Kirsten G. Bredvik, Michael B. Hoppa, Timothy A. Brown, Timothy A. Ryan
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202413564.
https://doi.org/10.1085/jgp.202413564
Published: 19 August 2026
View article titled, A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions
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Journal Articles

Crying time: Modeling tear formation

Alan M. Weinstein
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614026.
https://doi.org/10.1085/jgp.202614026
Published: 17 August 2026
View article titled, Crying time: Modeling tear formation
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Journal Articles

The mitochondrial swelling channel

Elizabeth A. Jonas, Eleanora Margulis, Ava Yu, Nelli Mnatsakanyan
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614066.
https://doi.org/10.1085/jgp.202614066
Published: 12 August 2026
View article titled, The mitochondrial swelling channel
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Journal Articles

ATP1A1 variants spring a leak

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614091.
https://doi.org/10.1085/jgp.202614091
Published: 11 August 2026
View article titled, ATP1A1 variants spring a leak
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Journal Articles

A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function

Augustus J. Lowry, Pengfei Liang, Maria A. Gonzalez Torres, Huanghe Yang
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202614003.
https://doi.org/10.1085/jgp.202614003
Published: 10 August 2026
View article titled, A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function
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Journal Articles

Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes

Arpan Bysack, H. Raghuraman
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202614000.
https://doi.org/10.1085/jgp.202614000
Published: 06 August 2026
View article titled, Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes
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Includes: Supplementary data
Journal Articles

Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation

In Special Collection:
Voltage-Gated Na Channels 2026
Boris S. Zhorov
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (5): e202614023.
https://doi.org/10.1085/jgp.202614023
Published: 06 August 2026
View article titled, Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation
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Journal Articles

Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies

Kate M. Crowther, Thibault R.H. Jouen-Tachoire, Peter Proks, Peter Rory Hall, Emma L. Veale, Janina Sörmann, Karin E.J. Rödström, Thomas Müller, Saskia B. Wortmann, Nina Barisic, Natalie Hauser, Vincenzo Salpietro, RaeLynn Forsyth, Linford Williams, Nora Derrabi, Carlos A. Bacino, Jill A. Rosenfeld, Henry Houlden, Simon Newstead, Caroline F. Wright, James Fasham, Alistair A. Mathie, Reza Maroofian, Stephen J. Tucker
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202613989.
https://doi.org/10.1085/jgp.202613989
Published: 06 August 2026
View article titled, Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies
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Includes: Supplementary data
Journal Articles

Giving structure meaning: Modelling the cellular synapse of excitation–contraction coupling in skeletal muscle

Werner Melzer
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614061.
https://doi.org/10.1085/jgp.202614061
Published: 30 July 2026
View article titled, Giving structure meaning: Modelling the cellular synapse of excitation–contraction coupling in skeletal muscle
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Journal Articles

Locking the TMEM16A chloride channel into its conductive state

Zhang Feng
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (5): e202614052.
https://doi.org/10.1085/jgp.202614052
Published: 30 July 2026
View article titled, Locking the TMEM16A chloride channel into its conductive state
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Journal Articles

Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail

Eduardo Rios, Gonzalo Pizarro
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202613968.
https://doi.org/10.1085/jgp.202613968
Published: 21 July 2026
View article titled, Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail
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Journal Articles

Electrophysiology in nanoscale compartments

Madeleine R. Howell, Rosalind J. Xu, Adam E. Cohen
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614011.
https://doi.org/10.1085/jgp.202614011
Published: 20 July 2026
View article titled, Electrophysiology in nanoscale compartments
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Includes: Supplementary data
Journal Articles

Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels

Philipp A.M. Schmidpeter, Crina M. Nimigean
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614025.
https://doi.org/10.1085/jgp.202614025
Published: 09 July 2026
View article titled, Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels
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Journal Articles

Kinetic reconstruction of graded membrane excitability in Paramecium

Takashi Tominaga, Yoko Tominaga
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202613977.
https://doi.org/10.1085/jgp.202613977
Published: 07 July 2026
View article titled, Kinetic reconstruction of graded membrane excitability in Paramecium
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Journal Articles

Evolution, hibernation, and inactivation of voltage-gated Na channels

John S. Willis
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202513923.
https://doi.org/10.1085/jgp.202513923
Published: 07 July 2026
View article titled, Evolution, hibernation, and inactivation of voltage-gated Na channels
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Journal Articles

Conformational changes upon pore blocker removal reveal conductive states of TMEM16A

Christina A. Stephens, Frank V. Marcoline, Christian J. Peters, Michael Grabe
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (5): e202513961.
https://doi.org/10.1085/jgp.202513961
Published: 02 July 2026
View article titled, Conformational changes upon pore blocker removal reveal conductive states of TMEM16A
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Includes: Supplementary data

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