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Journal Articles

Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944

Jinglang Sun, Juan de la Rosa Vázquez, Adriana Hernández-González, Vladimir Yarov-Yarovoy, Amy Lee
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513879.
https://doi.org/10.1085/jgp.202513879
Published: 05 January 2026
View article titled, Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944
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Includes: Supplementary data
Journal Articles

Manganese and intracellular Ca2+ handling

Godfrey L. Smith, David A. Eisner
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (2): e202513908.
https://doi.org/10.1085/jgp.202513908
Published: 26 December 2025
View article titled, Manganese and intracellular Ca2+ handling
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Journal Articles

A critical residue mediates proper assembly and gating of GIRK2 channels

Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513817.
https://doi.org/10.1085/jgp.202513817
Published: 19 December 2025
View article titled, A critical residue mediates proper assembly and gating of GIRK2 channels
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Includes: Supplementary data
Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2025) 158 (2): e202413705.
https://doi.org/10.1085/jgp.202413705
Published: 18 December 2025
View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2
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Includes: Supplementary data
Journal Articles

Cavβ dances the two-step with VSD II

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513935.
https://doi.org/10.1085/jgp.202513935
Published: 18 December 2025
View article titled, Cavβ dances the two-step with VSD II
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Journal Articles

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rios
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513877.
https://doi.org/10.1085/jgp.202513877
Published: 17 December 2025
View article titled, Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?
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Journal Articles

On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

Hridya Valia Madapally, Adel Hussein, Martin Wazar Eriksen, Bjørn Panyella Pedersen, David L. Stokes, Himanshu Khandelia
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513794.
https://doi.org/10.1085/jgp.202513794
Published: 12 December 2025
View article titled, On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC
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Includes: Supplementary data
Journal Articles

Towards a unified gating scheme for the CNBD ion channel family

Jenna L. Lin, Baron Chanda
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513849.
https://doi.org/10.1085/jgp.202513849
Published: 11 December 2025
View article titled, Towards a unified gating scheme for the CNBD ion channel family
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Includes: Supplementary data
Journal Articles

Novel binding mode for negative allosteric NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513872.
https://doi.org/10.1085/jgp.202513872
Published: 03 December 2025
View article titled, Novel binding mode for negative allosteric NMDA receptor modulators
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Includes: Supplementary data
Journal Articles

Subtype-selective targeting of NMDA receptors—A potent new compound emerges

Hiro Furukawa
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513920.
https://doi.org/10.1085/jgp.202513920
Published: 03 December 2025
View article titled, Subtype-selective targeting of NMDA receptors—A potent new compound emerges
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Journal Articles

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513835.
https://doi.org/10.1085/jgp.202513835
Published: 02 December 2025
View article titled, Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel
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Includes: Supplementary data
Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513890.
https://doi.org/10.1085/jgp.202513890
Published: 25 November 2025
View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels
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Journal Articles

Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility

Alejandro Alvarez-Arce, Geena E. Fritzmann, Hope V. Burnham, Kelly N. Araujo, Alexandra Peña, Lucas M. Wittenkeller, Hannah E. Cizauskas, David Y. Barefield
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 158 (1): e202413630.
https://doi.org/10.1085/jgp.202413630
Published: 19 November 2025
View article titled, Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility
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Includes: Supplementary data
Journal Articles

Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513811.
https://doi.org/10.1085/jgp.202513811
Published: 18 November 2025
View article titled, Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue
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Includes: Supplementary data
Journal Articles

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513800.
https://doi.org/10.1085/jgp.202513800
Published: 11 November 2025
View article titled, Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry
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Journal Articles

Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202413739.
https://doi.org/10.1085/jgp.202413739
Published: 05 November 2025
View article titled, Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit
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Includes: Supplementary data
Journal Articles

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

Leander A. Vonk, Osman Esen, Daan Hoomoedt, Rajvi M.N. Balesar, Coen A.C. Ottenheijm, Tyler J. Kirby
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513761.
https://doi.org/10.1085/jgp.202513761
Published: 03 November 2025
View article titled, Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture
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Includes: Supplementary data
Journal Articles

Correction: The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e20231347210212025C.
https://doi.org/10.1085/jgp.20231347210212025C
Published: 28 October 2025
View article titled, Correction: The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner
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Journal Articles

Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction

Noortje W.M. van den Braak, Samuel Kuehs, Greta Z. Peschke, Barbara Namer, Annette Lischka, Katja Eggermann, Christina Dumke, Vishal Sudha Bhagavath Eswaran, Stefan Nikolin, Joachim Weis, Jörg B. Schulz, Angelika Lampert, Ingo Kurth, Roman Rolke, Enrico Leipold, Maike F. Dohrn
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413691.
https://doi.org/10.1085/jgp.202413691
Published: 24 October 2025
View article titled, Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction
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Includes: Supplementary data
Journal Articles

The origins of oscillations

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202513904.
https://doi.org/10.1085/jgp.202513904
Published: 22 October 2025
View article titled, The origins of oscillations
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