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Journal Articles

Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels

Magnus Behringer, Jan Krumbach, Alessandro Porro, Andrea Saponaro, Dario DiFrancesco, Anna Moroni, Kay Hamacher, Gerhard Thiel
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513899.
https://doi.org/10.1085/jgp.202513899
Published: 03 April 2026
View article titled, Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels
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Journal Articles

Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations

Claire H. Levitt, Dominic Isaacs, Maria S. Hansen, Vira Kravets, Jennifer K. Briggs, Richard K.P. Benninger
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513867.
https://doi.org/10.1085/jgp.202513867
Published: 31 March 2026
View article titled, Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations
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Journal Articles

Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles

Manuel F. Muñoz, Collin Matsumoto, Paula Rhana, Declan Manning, Geoanna M. Bautista, Daniel M. Collier, L. Fernando Santana
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (3): e202513874.
https://doi.org/10.1085/jgp.202513874
Published: 31 March 2026
View article titled, Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles
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Journal Articles

Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Catherine Hoover Browne, Seong-won Han, Gerrie P. Farman, John E. Smith, Justin Kolb, Jochen Gohlke, Paul R. Langlais, Paola Tonino, Mei Methawasin, Robbert van der Pijl, Henk Granzier
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513891.
https://doi.org/10.1085/jgp.202513891
Published: 12 March 2026
View article titled, Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement
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Includes: Supplementary data
Journal Articles

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Lucas J. Handlin, Clémence Gieré, Nicolas L.A. Dumaire, Lyuba Salih, Aubin Moutal, Gucan Dai
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513925.
https://doi.org/10.1085/jgp.202513925
Published: 12 March 2026
View article titled, Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons
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Includes: Supplementary data
Journal Articles

Deep learning as a generator of sodium channel state hypotheses

Lisa Schmidt, Wojciech Kopec
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (3): e202513938.
https://doi.org/10.1085/jgp.202513938
Published: 10 March 2026
View article titled, Deep learning as a generator of sodium channel state hypotheses
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Journal Articles

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Gaogao He, Xiaoxi Li, Yanlin Huang, Conghan Wang, Minjie Tan, Qinglian Liu, Lei Zhou
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513819.
https://doi.org/10.1085/jgp.202513819
Published: 05 March 2026
View article titled, Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen
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Journal Articles

Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere

Angela C. Greenman, Willem de Lange, J. Carter Ralphe
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513889.
https://doi.org/10.1085/jgp.202513889
Published: 03 March 2026
View article titled, Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere
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Journal Articles

Putative RNA editing of a nicotinic receptor increases acetylcholine sensitivity

Cecilia M. Borghese, Ying Lu, Edward J. Bertaccini, Harold H. Zakon
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202413677.
https://doi.org/10.1085/jgp.202413677
Published: 23 February 2026
View article titled, Putative RNA editing of a nicotinic receptor increases acetylcholine sensitivity
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Journal Articles

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel

Yuki K. Maeda, Kentaro Kojima, Tomoe Y. Nakamura, Toru Nakatsu, Katsumasa Irie
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513855.
https://doi.org/10.1085/jgp.202513855
Published: 19 February 2026
View article titled, Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel
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Includes: Supplementary data
Journal Articles

JGP in 2026

David Eisner
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202613965.
https://doi.org/10.1085/jgp.202613965
Published: 17 February 2026
View article titled, JGP in 2026
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Journal Articles

Molecular dynamics analyses of CLDN15 pore size and charge selectivity

Sarah McGuinness, Pan Li, Ye Li, Shadi Fuladi, Sukanya Konar, Samaneh Sajjadi, Mohammed Sidahmed, Yueying Li, Le Shen, Fatemeh Khalili-Araghi, Christopher R. Weber
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513824.
https://doi.org/10.1085/jgp.202513824
Published: 12 February 2026
View article titled, Molecular dynamics analyses of CLDN15 pore size and charge selectivity
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Journal Articles

ID helps verify coincidence detection

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202613970.
https://doi.org/10.1085/jgp.202613970
Published: 11 February 2026
View article titled, ID helps verify coincidence detection
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Journal Articles

Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Thierry Cens, Matthieu Rousset, Claudine Menard, Mohamed Chahine, Claude Collet, Jean-Christophe Sandoz, Alain Chavanieu, Sebastien Estaran, Jean-Baptiste Thibaud, Patrick Bois, Pierre Charnet
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202413712.
https://doi.org/10.1085/jgp.202413712
Published: 10 February 2026
View article titled, Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence
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Journal Articles

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Luca M.G. Palloni, Nicole Sarno, Caterina Azzoni, Nicol Furia, Matteo E. Mangoni, Alessandro Porro, Teresa Neeman, Andrea Saponaro, Gerhard Thiel, Anna Moroni, Dario DiFrancesco
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513873.
https://doi.org/10.1085/jgp.202513873
Published: 06 February 2026
View article titled, AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia
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Includes: Supplementary data
Journal Articles

Coincidence detection supported by electrical synapses is shaped by the D-type K+ current

Antonella Dapino, Sebastián Curti
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (2): e202513883.
https://doi.org/10.1085/jgp.202513883
Published: 30 January 2026
View article titled, Coincidence detection supported by electrical synapses is shaped by the D-type K+ current
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Includes: Supplementary data
Journal Articles

A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations

Anthony L. Hessel, Katelyn M. Manross, Matthew M. Borkowski, Christopher D. Rand, Khoi Nguyen
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2026) 158 (2): e202513773.
https://doi.org/10.1085/jgp.202513773
Published: 28 January 2026
View article titled, A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations
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Journal Articles

The relationship between apparent potentiation and the magnitude of the control response

Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513894.
https://doi.org/10.1085/jgp.202513894
Published: 27 January 2026
View article titled, The relationship between apparent potentiation and the magnitude of the control response
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Journal Articles

Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944

Jinglang Sun, Juan de la Rosa Vázquez, Adriana Hernández-González, Vladimir Yarov-Yarovoy, Amy Lee
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513879.
https://doi.org/10.1085/jgp.202513879
Published: 05 January 2026
View article titled, Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944
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Includes: Supplementary data
Journal Articles

Manganese and intracellular Ca2+ handling

Godfrey L. Smith, David A. Eisner
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (2): e202513908.
https://doi.org/10.1085/jgp.202513908
Published: 26 December 2025
View article titled, Manganese and intracellular Ca2+ handling
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