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Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513890.
https://doi.org/10.1085/jgp.202513890
Published: 25 November 2025
View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels
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Journal Articles

Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility

Alejandro Alvarez-Arce, Geena E. Fritzmann, Hope V. Burnham, Kelly N. Araujo, Alexandra Peña, Lucas M. Wittenkeller, Hannah E. Cizauskas, David Y. Barefield
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 158 (1): e202413630.
https://doi.org/10.1085/jgp.202413630
Published: 19 November 2025
View article titled, Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility
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Includes: Supplementary data
Journal Articles

Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513811.
https://doi.org/10.1085/jgp.202513811
Published: 18 November 2025
View article titled, Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue
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Includes: Supplementary data
Journal Articles

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513800.
https://doi.org/10.1085/jgp.202513800
Published: 11 November 2025
View article titled, Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry
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Journal Articles

Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202413739.
https://doi.org/10.1085/jgp.202413739
Published: 05 November 2025
View article titled, Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit
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Includes: Supplementary data
Journal Articles

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

Leander A. Vonk, Osman Esen, Daan Hoomoedt, Rajvi M.N. Balesar, Coen A.C. Ottenheijm, Tyler J. Kirby
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513761.
https://doi.org/10.1085/jgp.202513761
Published: 03 November 2025
View article titled, Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture
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Includes: Supplementary data
Journal Articles

Correction: The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e20231347210212025C.
https://doi.org/10.1085/jgp.20231347210212025C
Published: 28 October 2025
View article titled, Correction: The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner
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Journal Articles

Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction

Noortje W.M. van den Braak, Samuel Kuehs, Greta Z. Peschke, Barbara Namer, Annette Lischka, Katja Eggermann, Christina Dumke, Vishal Sudha Bhagavath Eswaran, Stefan Nikolin, Joachim Weis, Jörg B. Schulz, Angelika Lampert, Ingo Kurth, Roman Rolke, Enrico Leipold, Maike F. Dohrn
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413691.
https://doi.org/10.1085/jgp.202413691
Published: 24 October 2025
View article titled, Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction
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Includes: Supplementary data
Journal Articles

The origins of oscillations

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202513904.
https://doi.org/10.1085/jgp.202513904
Published: 22 October 2025
View article titled, The origins of oscillations
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Journal Articles

A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness

Sho Horie, Konan Sakuta, Keigo Tada, Haruki Tokumoto, Taketo Nishimoto, Katsunori Kitano, Masao Tachibana, Chieko Koike
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202413749.
https://doi.org/10.1085/jgp.202413749
Published: 16 October 2025
View article titled, A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness
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Includes: Supplementary data
Journal Articles

SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1

Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K. Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D. Gada, Takeharu Kawano, Meng Cui, Leigh D. Plant
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513837.
https://doi.org/10.1085/jgp.202513837
Published: 14 October 2025
View article titled, SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1
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Includes: Supplementary data
Journal Articles

Voltage-gated sodium channels: Mechanisms, disease, and a growing research community

Hugues Abriel, Angelika Lampert
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202513878.
https://doi.org/10.1085/jgp.202513878
Published: 10 October 2025
View article titled, Voltage-gated sodium channels: Mechanisms, disease, and a growing research community
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Journal Articles

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, Rubem Carlos Araújo Guedes
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202513843.
https://doi.org/10.1085/jgp.202513843
Published: 07 October 2025
View article titled, Cortical spreading depression dynamics are altered by topical D2 receptor ligands
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Journal Articles

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

Rosa Scala, Maya Mukadam, Yuezhou Chen, Courtney Frazier, Nathaniel W. York, Robert C. Tryon, Gretchen A. Meyer, Colin G. Nichols
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513781.
https://doi.org/10.1085/jgp.202513781
Published: 07 October 2025
View article titled, Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice
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Journal Articles

PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating

Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, Sun-Joo Lee
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202513864.
https://doi.org/10.1085/jgp.202513864
Published: 03 October 2025
View article titled, PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating
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Journal Articles

NALCN/Cch1 channelosome subunits originated in early eukaryotes

Adriano Senatore, Tatiana D. Mayorova, Luis A. Yañez-Guerra, Wassim Elkhatib, Brian Bejoy, Philippe Lory, Arnaud Monteil
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2025) 157 (6): e202413636.
https://doi.org/10.1085/jgp.202413636
Published: 05 September 2025
View article titled, NALCN/Cch1 channelosome subunits originated in early eukaryotes
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Includes: Supplementary data
Journal Articles

Investigating the role of the I–II linker in Nav1.5 channel function

Emily Wagner, Martina Marras, Shashi Kumar, Jacob Kelley, Kiersten Ruff, Jonathan Silva
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413692.
https://doi.org/10.1085/jgp.202413692
Published: 04 September 2025
View article titled, Investigating the role of the I–II linker in Nav1.5 channel function
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Includes: Supplementary data
Journal Articles

Resolving zone-specific regulation of cardiac myosin

Shane R. Nelson
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (6): e202513838.
https://doi.org/10.1085/jgp.202513838
Published: 28 August 2025
View article titled, Resolving zone-specific regulation of cardiac myosin
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Journal Articles

Skeletal muscle gets some help down the stretch

Ben Short
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513866.
https://doi.org/10.1085/jgp.202513866
Published: 26 August 2025
View article titled, Skeletal muscle gets some help down the stretch
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Journal Articles

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Bin Sun, Alec Loftus, Brandon Beh Goh Beh, Aalaythia Hepburn, Jonathan A. Kirk, Peter M. Kekenes-Huskey
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413737.
https://doi.org/10.1085/jgp.202413737
Published: 26 August 2025
View article titled, GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle
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Includes: Supplementary data