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A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Adam Feher, Geraldo Jorge Domingos, Martina Piga, Tihomir Tomašič, Nace Zidar, Zoltan Varga

J Gen Physiol (2026) 158 (4): e202513945.

https://doi.org/10.1085/jgp.202513945

Published: 28 May 2026

View article titled, A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Includes: Supplementary data

Journal Articles

Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Varun Verma, Ethan S. Lindgren, Marc H. Levin, Onur Cil, Lukmanee Tradtrantip, Rongshan Yan, Neel D. Pasricha, Alan S. Verkman

J Gen Physiol (2026) 158 (4): e202513958.

https://doi.org/10.1085/jgp.202513958

Published: 22 May 2026

View article titled, Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Journal Articles

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

Yenisleidy Lorenzo-Ceballos, Pedro L. Martinez-Espinosa, Xiao-Ming Xia, Christopher J. Lingle

J Gen Physiol (2026) 158 (4): e202613985.

https://doi.org/10.1085/jgp.202613985

Published: 22 May 2026

View article titled, Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

Includes: Supplementary data

Journal Articles

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Magalí Colomer-Molera, Daniel Sastre, Antonio Felipe

J Gen Physiol (2026) 158 (4): e202513936.

https://doi.org/10.1085/jgp.202513936

Published: 20 May 2026

View article titled, Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Includes: Supplementary data

Journal Articles

Subunit composition of the K_ATP channels that modulate contractility of skeletal muscle during fatigue

Rosa Scala, Yuezhou Chen, Berk Mizrak, Gretchen A. Meyer, Colin G. Nichols

J Gen Physiol (2026) 158 (4): e202613986.

https://doi.org/10.1085/jgp.202613986

Published: 20 May 2026

View article titled, Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue

Journal Articles

Dysferlin’s C2A domain supports normal Ca²⁺ signaling and membrane repair in dysferlin-null myofibers

Valeriy Lukyanenko, Joaquin Muriel, Kassidy K. Banford, Thomas A. Kwiatkowski, Hannah R. Bulgart, Noah Weisleder, Robert J. Bloch

J Gen Physiol (2026) 158 (4): e202513844.

https://doi.org/10.1085/jgp.202513844

Published: 14 May 2026

View article titled, Dysferlin’s C2A domain supports normal Ca2+ signaling and membrane repair in dysferlin-null myofibers

Includes: Supplementary data

Journal Articles

Brain voltage-gated Ca²⁺ channels and calmodulin: Teaming up in calmodulinopathies?

Jörg Striessnig

J Gen Physiol (2026) 158 (4): e202613981.

https://doi.org/10.1085/jgp.202613981

Published: 13 May 2026

View article titled, Brain voltage-gated Ca2+ channels and calmodulin: Teaming up in calmodulinopathies?

Journal Articles

Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Yichen Liu, Cesar A. Amaya-Rodriguez, Victoria Collio, Gabriel Ibañez, Ramón Latorre, Francisco Bezanilla

J Gen Physiol (2026) 158 (4): e202613980.

https://doi.org/10.1085/jgp.202613980

Published: 07 May 2026

View article titled, Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Journal Articles

Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish

Amin Akhshi, Myriah Haggard, Mariana M. Marquez, Saeed Farjami, Maurice J. Chacron, Anmar Khadra

J Gen Physiol (2026) 158 (4): e202513841.

https://doi.org/10.1085/jgp.202513841

Published: 29 April 2026

View article titled, Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish

Includes: Supplementary data

Journal Articles

Cholesterol pools cooperate to modulate HCN channels

Ben Short

J Gen Physiol (2026) 158 (3): e202614013.

https://doi.org/10.1085/jgp.202614013

Published: 24 April 2026

View article titled, Cholesterol pools cooperate to modulate HCN channels

Journal Articles

Calmodulinopathy variants impair Ca_V1.3 and Ca_V2.1 regulation

John W. Hussey, Emily DeMarco, Deborah DiSilvestre, Malene Brohus, Ana-Octavia Busuioc, Emil D. Iversen, Helene H. Jensen, Mette Nyegaard, Michael T. Overgaard, Manu Ben-Johny, Ivy E. Dick

J Gen Physiol (2026) 158 (3): e202413734.

https://doi.org/10.1085/jgp.202413734

Published: 24 April 2026

View article titled, Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation

Includes: Supplementary data

Journal Articles

Missense mutation causes multiple defects in Na_v1.4 channel gating and leads to an SCN4A-associated overlap phenotype

Tatiana B. Tikhonova, Artem A. Sharkov, Aysylu F. Murtazina, Nadezda V. Mashkovtseva, Boris S. Zhorov, Alexander A. Vassilevski

J Gen Physiol (2026) 158 (3): e202413706.

https://doi.org/10.1085/jgp.202413706

Published: 21 April 2026

View article titled, Missense mutation causes multiple defects in Nav1.4 channel gating and leads to an SCN4A-associated overlap phenotype

Includes: Supplementary data

Journal Articles

Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane

George W.S. Burwood, Tianying Ren, Edward V. Porsov, Alfred L. Nuttall, Anders Fridberger

J Gen Physiol (2026) 158 (3): e202413611.

https://doi.org/10.1085/jgp.202413611

Published: 21 April 2026

View article titled, Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane

Includes: Supplementary data

Journal Articles

Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels

Magnus Behringer, Jan Krumbach, Alessandro Porro, Andrea Saponaro, Dario DiFrancesco, Anna Moroni, Kay Hamacher, Gerhard Thiel

J Gen Physiol (2026) 158 (3): e202513899.

https://doi.org/10.1085/jgp.202513899

Published: 03 April 2026

View article titled, Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels

Journal Articles

Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations

Claire H. Levitt, Dominic Isaacs, Maria S. Hansen, Vira Kravets, Jennifer K. Briggs, Richard K.P. Benninger

J Gen Physiol (2026) 158 (3): e202513867.

https://doi.org/10.1085/jgp.202513867

Published: 31 March 2026

View article titled, Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations

Journal Articles

Beat-locked ATP microdomains in the sinoatrial node map a Ca²⁺-timed energetic hierarchy and regional pacemaker roles

Manuel F. Muñoz, Collin Matsumoto, Paula Rhana, Declan Manning, Geoanna M. Bautista, Daniel M. Collier, L. Fernando Santana

J Gen Physiol (2026) 158 (3): e202513874.

https://doi.org/10.1085/jgp.202513874

Published: 31 March 2026

View article titled, Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles

Journal Articles

Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Catherine Hoover Browne, Seong-won Han, Gerrie P. Farman, John E. Smith, Justin Kolb, Jochen Gohlke, Paul R. Langlais, Paola Tonino, Mei Methawasin, Robbert van der Pijl, Henk Granzier

J Gen Physiol (2026) 158 (3): e202513891.

https://doi.org/10.1085/jgp.202513891

Published: 12 March 2026

View article titled, Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Includes: Supplementary data

Journal Articles

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Lucas J. Handlin, Clémence Gieré, Nicolas L.A. Dumaire, Lyuba Salih, Aubin Moutal, Gucan Dai

J Gen Physiol (2026) 158 (3): e202513925.

https://doi.org/10.1085/jgp.202513925

Published: 12 March 2026

View article titled, Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Includes: Supplementary data

Journal Articles

Deep learning as a generator of sodium channel state hypotheses

Lisa Schmidt, Wojciech Kopec

J Gen Physiol (2026) 158 (3): e202513938.

https://doi.org/10.1085/jgp.202513938

Published: 10 March 2026

View article titled, Deep learning as a generator of sodium channel state hypotheses

Journal Articles

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Gaogao He, Xiaoxi Li, Yanlin Huang, Conghan Wang, Minjie Tan, Qinglian Liu, Lei Zhou

J Gen Physiol (2026) 158 (3): e202513819.

https://doi.org/10.1085/jgp.202513819

Published: 05 March 2026

View article titled, Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

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A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Subunit composition of the K_ATP channels that modulate contractility of skeletal muscle during fatigue

Dysferlin’s C2A domain supports normal Ca²⁺ signaling and membrane repair in dysferlin-null myofibers

Brain voltage-gated Ca²⁺ channels and calmodulin: Teaming up in calmodulinopathies?

Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish

Cholesterol pools cooperate to modulate HCN channels

Calmodulinopathy variants impair Ca_V1.3 and Ca_V2.1 regulation

Missense mutation causes multiple defects in Na_v1.4 channel gating and leads to an SCN4A-associated overlap phenotype

Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane

Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels

Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations

Beat-locked ATP microdomains in the sinoatrial node map a Ca²⁺-timed energetic hierarchy and regional pacemaker roles

Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Deep learning as a generator of sodium channel state hypotheses

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

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