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Research News

JGP study indicates that β-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes.


Excitation–Contraction Coupling

Asghari et al. analyzed a series of RyR2 phosphorylation mutants, all of which altered the structure of the dyad and its response to the β-agonist isoproterenol. Their results suggest a direct link between the phosphorylation state of the channel tetramer and the microarchitecture of the dyad.

Acute and long-term treatment with tirasemtiv, a fast troponin skeletal muscle activator, improves skeletal and respiratory muscle function in a mouse model for nemaline myopathy type 3, caused by a p.Asp286Cys variant in ACTA1.

Benucci et al. characterize a new mouse model carrying a mutation in RyR1 identified in a severely affected child. Their model reveals that homozygosity for this pathophysiologically relevant mutation functionally impacts muscle function and alters calcium homeostasis.

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