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Outward single-channel currents from TRPV1 channels carried by the indicated ion (upper) and inward currents carried by sodium (lower). Also shown are extracellular views of the open and closed structures of TRPV1. Both the single channel conductance and channel gating are modulated by the permeant ion. Image © García-Ávila et al., 2023. https://doi.org/10.1085/jgp.202313422. - PDF Icon PDF LinkTable of Contents
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Interpretation of presynaptic phenotypes of synaptic plasticity in terms of a two-step priming process
Conceiving synaptic vesicle priming as a dynamic reversible process opens up new interpretations of data on neurotransmitter release.
Articles
Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects
VPC01091.4 and AAL-149 are FTY720 analogs that inhibit TRPM7 without targeting S1P receptors and exert multimodal anti-inflammatory effects in vivo. In a mouse endotoxemia model, VPC01091.4 reduces inflammation and disease severity without impacting blood lymphocyte counts.
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP
Shen et al. show that mutating countercharge residues in Ciona intestinalis voltage-sensing phosphatase result in the formation of a continuous water path through the voltage-sensing domain and the generation of omega currents. Their work reveals a novel role for voltage-sensor countercharges.
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger
Enamel-forming cells direct the transport of calcium out of the cell to help mineralize the enamel crystals. Sodium/calcium exchangers are proteins that efficiently extrude calcium. In enamel cells, NCKX proteins dominate this function explaining why patients with defective NCKX4 have enamel defects.
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels
TRPV1 ion channels are important players in thermal and chemical sensation and have roles in pathological states. In this work, Garcia-Ávila et al. employ single-channel recordings to observe that large cations are more permeable than smaller ones and uncover fast conformational changes that are distinctly modulated by the cation occupying the pore.
