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Cover Image
Cover Image
Cover picture: Control of calcium release in heart muscle: top, EKG of a mouse with CPVT transitions from sinus rhythm through extrasystoles (arrows) to bidirectional tachycardia; middle, a calcium spark and its intra-SR blink reflect calcium release at the multimolecular couplon; bottom, the newly resolved near-atomic structure of the calcium release channel boosts understanding of channel diastolic hyperactivity leading to CPVT. The cover is composed of unpublished images, records, and design ideas from Lothar A. Blatter, Mark B. Cannell, S.R. Wayne Chen, Angela Dulhunty, Sándor Györke, Björn Knollmann, Rafael Mejía-Álvarez, Eduardo Ríos, Eric A. Sobie, and Filip Van Petegem. Final design by Rochelle Ritacco.
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Perspective
Perspectives on “Control of Ca release from within the cardiac sarcoplasmic reticulum”
Five groups of experts unravel the complex modulation of a function crucial for the beating heart.
Quenching the spark: Termination of CICR in the submicroscopic space of the dyad
Cannell and Kong discuss the different termination mechanisms proposed for CICR in cardiac myocytes.
Ambiguous interactions between diastolic and SR Ca2+ in the regulation of cardiac Ca2+ release
Sobie et al. highlight unresolved issues concerning the regulation of sarcoplasmic reticulum calcium release in cardiac myocytes.
The intricacies of atrial calcium cycling during excitation-contraction coupling
Blatter discusses the initiation and spread of Ca release, Ca store depletion, and release termination in atrial myocytes.
Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+
Jones et al. propose that SR luminal Ca2+ regulates RyR2 activity via a luminal Ca2+ sensor distinct from the cytosolic Ca2+ sensor.
The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis
Györke et al. discuss the role of sarcoplasmic reticulum Ca2+ in cardiac refractoriness and pathological implications.
