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Issues

ISSN 0022-1295
EISSN 1540-7748
In this Issue

Editorial

JGP 100th Anniversary

As JGP approaches its 100th year, dissemination of science is more important than ever.

Research News

New JGP study models how sinoatrial node pacemaker activity changes in aged hearts.

Commentary

Slow fusion pore expansion could retain molecules within vesicles, enabling a chemical reaction that modifies secreted products.

Milestone in Physiology

JGP 100th Anniversary

JGP hosts key papers that shaped the epithelial transport field.

Alvarez and Latorre describe the long-lasting contribution of Goldman’s equation to our understanding of membrane transport.

Article

A lumenal secretory granule protein can slow fusion pore dilation and thus its own discharge. Bohannon et al. demonstrate another outcome: the creation of a nanoscale chemical reaction chamber for granule contents in which the pH is suddenly neutralized upon fusion.

Pacemaker function deteriorates in advanced age. Behar and Yaniv show that both intracellular and membrane mechanisms are responsible for age-associated pacemaker function deterioration and explain why the maximal beating rate is restored as a result of changes in sensitivity of HCN4 to cAMP and phospholamban to PKA.

The phenylalanine-glycine–repeat nucleoporins are essential for transport through the nuclear pore complex. Pulupa et al. observe reptation of these nucleoporins on a physiological timescale in coarse-grained computational simulations.

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