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Cover Image
Cover Image
Cover picture: A nuclear pore complex (NPC) sitting in the light blue grid of a nuclear envelope. A coarse-grained computational model reveals the dynamics of the phenyalanine-glycine–rich filaments (FG-Nups) that are anchored, in eightfold symmetry, along the internal periphery of the NPC and whose ordered, but unstructured domains fill the lumen of the pore. Each color represents a different ring of FG-Nups (see Research Article by Pulupa et al., 951–966).
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Editorial
100 years and counting: JGP celebrates its centenary
As JGP approaches its 100th year, dissemination of science is more important than ever.
Research News
Modeling pacemaker deterioration with age
New JGP study models how sinoatrial node pacemaker activity changes in aged hearts.
Commentary
Chemistry in a vesicle
Slow fusion pore expansion could retain molecules within vesicles, enabling a chemical reaction that modifies secreted products.
Milestone in Physiology
Epithelial transport in The Journal of General Physiology
JGP hosts key papers that shaped the epithelial transport field.
The enduring legacy of the “constant-field equation” in membrane ion transport
Alvarez and Latorre describe the long-lasting contribution of Goldman’s equation to our understanding of membrane transport.
Article
Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo
A lumenal secretory granule protein can slow fusion pore dilation and thus its own discharge. Bohannon et al. demonstrate another outcome: the creation of a nanoscale chemical reaction chamber for granule contents in which the pH is suddenly neutralized upon fusion.
Age-related pacemaker deterioration is due to impaired intracellular and membrane mechanisms: Insights from numerical modeling
Pacemaker function deteriorates in advanced age. Behar and Yaniv show that both intracellular and membrane mechanisms are responsible for age-associated pacemaker function deterioration and explain why the maximal beating rate is restored as a result of changes in sensitivity of HCN4 to cAMP and phospholamban to PKA.
A coarse-grained computational model of the nuclear pore complex predicts Phe-Gly nucleoporin dynamics
The phenylalanine-glycine–repeat nucleoporins are essential for transport through the nuclear pore complex. Pulupa et al. observe reptation of these nucleoporins on a physiological timescale in coarse-grained computational simulations.
