Localized calcium release from ryanodine-sensitive stores in large dense core vesicles may modulate secretion of neuropeptides from neurohypophysial terminals.
Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel
Extracellular anions more permeant than Cl− modulate TMEM16B gating to promote channel opening, whereas less permeant anions favor channel closure.
After illumination, rod photoreceptors show a paradoxical increase in sensitivity to light.
VcINDY, a bacterial homolog of transporters implicated in lifespan in fruit flies and insulin resistance in mammals, is a high affinity, electrogenic, Na+-dependent dicarboxylate transporter.
The ATP activation signal in trimeric P2X2 receptors propagates down individual subunits before spreading to all three at the level of the pore.
T-tubule uncoupling from the plasma membrane leads to myocardial contractile abnormalities.