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Cover Image
Cover Image
Cover picture: A rabbit cardiac sinoatrial node pacemaker cell, stained with an immunoflurescent antibody to the sarcoplasmic reticulum calcium pump SERCA2a, showing that the free SR network fills the cell. In contrast, the ryanodine receptors in the junctional SR are largely confined immediately below the surface membrane (not depicted). Numerical modeling shows that this produces a distinctive recirculation of calcium within the cell (see research article by Stern et al., 577–604).
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Generally Physiological
Review
Article
The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding
The cytoplasmic “cage” domain of the bacterial MscS channel senses macromolecular crowding to promote channel inactivation and prevent excessive loss of small osmolytes.
Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle
Angiotensin signaling promotes interactions between AKAP150, PKC, and TRPV4 channels to form signaling domains that control Ca2+ influx into arterial myocytes.
Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells
Numerical modeling indicates that hierarchical clustering of ryanodine receptors in cells of the sinoatrial node is crucial to the calcium clock and thereby to regulation of heart rate.
Intracellular calcium movements during relaxation and recovery of superfast muscle fibers of the toadfish swimbladder
Ca2+ movements during intercall intervals in superfast toadfish swimbladder muscle fibers depend on the accumulation of Ca2+ on parvalbumin and a consequent slow rate of Ca2+ pumping.
State-dependent block of Orai3 TM1 and TM3 cysteine mutants: Insights into 2-APB activation
Residue E165, in transmembrane helix 3, participates in formation of the dilated pore of the 2-APB–activated Orai3 channel but not that of the more selective store-operated Orai3 pore.
State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen
Singlet oxygen acts through a histidine residue to delay HCN channel deactivation and enhance voltage-insensitive current.
Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains
Conserved acidic and aromatic residues in the four sodium channel voltage-sensor domains make domain-specific functional contributions.
