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Issues

Editorial

We are pleased to welcome several new JGP Editorial Advisory Board members.

Generally Physiological

Article

AKAP79/150 and AKAP15 exert functionally antagonistic effects on CaV1.2 channels.

The Ca2+ selectivity of CRAC channels depends on the kinetics of ion entry and exit as well as the steady-state Ca2+ binding affinity.

Arachidonic acid (AA)-regulated Ca2+ (ARC) currents and leukotriene C4 (LTC4)-regulated Ca2+ (LRC) currents are mediated by the same populations of proteins.

Residues I696 and W697 are crucial to coupling between the TRPV1 ligand- and voltage-sensing domains and the channel pore.

Continuous helices extending from the transmembrane region to the cytoplasmic region form a dimeric interface to regulate activation of the voltage-gated H+ channel.

Myosim, a computer model of muscle contraction, includes molecular-level effects and incorporates dynamic coupling of myosin heads and binding sites.

Methods and Approaches

A Bayesian approach can be used to determine the reliability of estimated parameters in biophysical models.

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