Issues

Cover picture: Schematic drawing depicting a single subunit of an Elk K⁺ channel. Voltage sensor residues that mediate divalent cation block of voltage activation are shown. Acidic residues at positions D/E5 and D6 are unique to the Ether-a-go-go superfamily among K⁺ channels. These EAG-specifi c acidic residues make voltage activation of Eag, Elk, and Erg channels highly sensitive to external pH changes (see research article by Kazmierczak, 721–735).