Issues

Cover picture: N-current enhancement and inhibition occurs by arachidonic acid (AA) interacting with Ca_V2.2 at two different sites. Inhibition predominates (top) in β3-containing channels. However, coexpression of palmitoylated β2a with Ca_V2.2 blocks inhibition, revealing latent enhancement (middle; see article by Heneghan et al., 369–384). Deletion of two amino acids in Ca_V2.2's I-II linker reorients β2a, such that current inhibition is regained even in the presence of palmitoylated β2a (bottom; see article by Mitra-Ganguli et al., 385–396).