Issues

Cover picture: S6 mutations causing constitutive activation of hERG channels. The mutant channels are conductive at negative potentials (top left), their tail currents fail to decay to baseline (middle left) and have slower time constants (bottom left). Four energy-minimized models with open (top) and closed (bottom) states viewed laterally (left) and from the cytosol (right). In the closed state, Y667 and S668 from adjacent subunits make contact, forming a ring from which the Q664 side chains extend toward the pore axis and occlude the pore (see article by Wynia-Smith et al., 507–520).