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Communication | Ion Channels in Health and Disease
| August 06 2026
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Gain-of-function mutations in TASK channelopathies
Kate M. Crowther, Thibault R.H. Jouen-Tachoire, Peter Proks, Peter Rory Hall, Emma L. Veale, Janina Sörmann, Karin E.J. Rödström, Thomas Müller, Saskia B. Wortmann, Nina Barisic, Natalie Hauser, Vincenzo Salpietro, RaeLynn Forsyth, Linford Williams, Nora Derrabi, Carlos A. Bacino, Jill A. Rosenfeld, Henry Houlden, Simon Newstead, Caroline F. Wright, James Fasham, Alistair A. Mathie, Reza Maroofian, Stephen J. Tucker
In this study, Crowther and colleagues report new disease-causing variants in the TASK-1 and TASK-3 potassium channels responsible for two different neurodevelopmental disorders. They also examine the structural and functional properties of these variants and examine their effects when incorporated into heteromeric TASK-1/TASK-3 channels.
Article | Ion Channels in Health and Disease
| August 06 2026
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Cholesterol reorganizes slide helix of KirBac1.1
Arpan Bysack, H. Raghuraman
Bysack and Raghuraman show specific lipid–protein interactions mediate the cholesterol-induced reorganization of the slide helix in membranes during cholesterol-dependent regulation of KirBac1.1. Importantly, they hypothesize that the slide helix movement might function as a lipid-sensitive “conformational-switch” controlling KirBac1.1 gating.
Article | Voltage-Gated Na Channels 2026
| August 06 2026
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Aconitine and bulleyaconitine in sodium channel
Boris S. Zhorov
Sodium channel antagonist bulleyaconitine and agonist aconitine bind in the pore-domain fenestration I/II and stabilize the open activation gate. Aconitine transiently chelates passing sodium ions, while protonated bulleyaconitine blocks the permeation.
Article
| July 21 2026
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Allosteric activation of calcium release in muscle
Eduardo Rios, Gonzalo Pizarro
The contraction of skeletal muscles is turned on by Ca2+ released from the cellular store by RyR channels in a quasi-crystalline array, half of which only have contacts with neighbor RyRs. Rios and Pizarro’s model assumes these channels to be controlled allosterically by their neighbors and matches quantitatively observations of Ca2+ release gathered over decades.
Article
| July 20 2026
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Nanoscale electrophysiology
Madeleine R. Howell, Rosalind J. Xu, Adam E. Cohen
Bioelectrical signaling is important in many small structures, such as bacteria, viruses, and intracellular vesicles. The dynamics in small structures are strongly affected by stochastic gating of single ion channels. Howell et al. provide a framework for predicting and interpreting bioelectrical dynamics in small structures.
Article
| July 07 2026
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Reconstructing Paramecium graded excitability
Takashi Tominaga, Yoko Tominaga
We developed a kinetic framework for the major membrane-current components in Paramecium. The framework integrates late-component, leak, and inward Ca2+ currents, including Ca2+-dependent inactivation and slow recovery. It reproduces graded membrane responses under the present recording conditions.
Hypothesis | Ion Channels in Health and Disease
| July 07 2026
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Fast and slow inactivation in the cold
John S. Willis
Hearts of hibernating mammals continue to beat at near 0°C thanks to continued excitability. Several members of a minor group of voltage-gated Na channels in the heart are found to contain a mutation unique to hibernators. Molecular details of this mutation may help to explain the continued activity of the heart in the cold.

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Journal of General Physiology Cover Image for Volume 158, Issue 4
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Volume 158,
Issue 4,
6 July 2026
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Reviews & Opinions

Commentary
| July 30 2026
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Modelling couplons
Werner Melzer
Couplons are large multi-protein clusters consisting of CaV1.1 and RyR1 channels that connect SR and transverse tubulus in skeletal muscle cells and permit voltage-controlled Ca2+ release. Rios and Pizarro (2026) simulate allosteric interactions within the couplon using Markov chain modelling to successfully describe many characteristics of whole-cell and microdomain Ca2+ signals.
Commentary | Chloride Channels and Transporters
| July 30 2026
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TM3–TM4 interactions in TMEM16A gating
Zhang Feng
Feng discusses how a hydrophobic interaction network between TM3 and TM4 stabilizes an ion-conductive conformation of the TMEM16A chloride channel. Comparison with TMEM16 lipid scramblases suggests that functional diversity across the TMEM16 family may arise from differences in the stability of TM3–TM4 interactions and the resulting distinct TM4 rearrangements.
Review
| July 09 2026
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Predictive power of ion channel models
Philipp A.M. Schmidpeter, Crina M. Nimigean
This Review highlights how structurally simple prokaryotic potassium channels have consistently informed mechanisms in complex eukaryotic channels. By integrating structural and functional insights, the authors show that bacterial models remain powerful tools for generating hypotheses about regulatory principles across channel families.
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Special Collections

Neuroscience 2025

Highlighting recent articles addressing a wide variety of neuroscience research.

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