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The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T cells

Marco Ongaro, Romane Thouenon, Isaac Crespo, Alexandre Dumez, Mélanie Charmoy, Eduardo Roman Camacho, Victoria J. Morel, Daniela Cropp, Emma Desponds, Giulio Zanette, Yi-Chuan Wang, Letizia Vergili, Laure Tillé, Inés Di Resta, Marine M. Leblond, Jésus Corria Osorio, Ping-Chih Ho, Werner Held, Grégory Verdeil

J Exp Med (2026) 223 (8): e20252115.

https://doi.org/10.1084/jem.20252115

Published: 22 June 2026

View article titled, The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells

Includes: Supplementary data

Journal Articles

Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment

Sang Hun Lee, Melanie Charmoy, Audrey Romano, Andrea Paun, Mariana M. Chaves, Frederick O. Cope, David A. Ralph, David L. Sacks

J Exp Med (2017) 215 (1): 357–375.

https://doi.org/10.1084/jem.20171389

Published: 15 December 2017

View article titled, Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment

Includes: Supplementary data