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Synthetic soldiers: Turning T cells into immortal warriors

Nicholas P. Restifo, Luca Gattinoni

J Exp Med (2024) 221 (5): e20240258.

https://doi.org/10.1084/jem.20240258

Published: 18 April 2024

View article titled, Synthetic soldiers: Turning T cells into immortal warriors

Journal Articles

Cish actively silences TCR signaling in CD8⁺ T cells to maintain tumor tolerance

J Exp Med (2015) 212 (12): 2095–2113.

https://doi.org/10.1084/jem.20150304

Published: 02 November 2015

View article titled, Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Journal Articles

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection

Kyla D. Omilusik, J. Adam Best, Bingfei Yu, Steven Goossens, Alexander Weidemann, Jessica V. Nguyen, Eve Seuntjens, Agata Stryjewska, Christiane Zweier, Rahul Roychoudhuri, Luca Gattinoni, Lynne M. Bird, Yujiro Higashi, Hisato Kondoh, Danny Huylebroeck, Jody Haigh, Ananda W. Goldrath

J Exp Med (2015) 212 (12): 2027–2039.

https://doi.org/10.1084/jem.20150194

Published: 26 October 2015

View article titled, Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection

Includes: Supplementary data

Journal Articles

Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

J Exp Med (2013) 210 (10): 1961–1976.

https://doi.org/10.1084/jem.20122508

Published: 02 September 2013

View article titled, Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

Includes: Supplementary data

Journal Articles

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8⁺ T cells

Luca Gattinoni, Steven E. Finkelstein, Christopher A. Klebanoff, Paul A. Antony, Douglas C. Palmer, Paul J. Spiess, Leroy N. Hwang, Zhiya Yu, Claudia Wrzesinski, David M. Heimann, Charles D. Surh, Steven A. Rosenberg, Nicholas P. Restifo

J Exp Med (2005) 202 (7): 907–912.

https://doi.org/10.1084/jem.20050732

Published: 03 October 2005

View article titled, Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 + T cells

Includes: Supplementary data

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Synthetic soldiers: Turning T cells into immortal warriors

Cish actively silences TCR signaling in CD8⁺ T cells to maintain tumor tolerance

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection

Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8⁺ T cells

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Update search

Synthetic soldiers: Turning T cells into immortal warriors

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection

Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 + T cells

Email alerts

This Feature Is Available To Subscribers Only

Cish actively silences TCR signaling in CD8⁺ T cells to maintain tumor tolerance

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8⁺ T cells