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Bruce Beutler
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Journal Articles

Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy

In Special Collection:
JEM Cancer Collection 2025
Hexin Shi, Dawson Medler, Jianhui Wang, Rachel Browning, Aijie Liu, Sara Schneider, Claudia Duran Bojorquez, Ashwani Kumar, Xiaohong Li, Jiexia Quan, Sara Ludwig, James J. Moresco, Chao Xing, Eva Marie Y. Moresco, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240797.
https://doi.org/10.1084/jem.20240797
Published: 29 October 2024
View articletitled, Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy
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Includes: Supplementary data
Journal Articles

Viable mutations of mouse midnolin suppress B cell malignancies

In Special Collection:
Mechanisms and Models of Cancer 2024
Xue Zhong, Nagesh Peddada, James J. Moresco, Jianhui Wang, Yiao Jiang, Jonathan J. Rios, Eva Marie Y. Moresco, Jin Huk Choi, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (6): e20232132.
https://doi.org/10.1084/jem.20232132
Published: 16 April 2024
View articletitled, Viable mutations of mouse midnolin suppress B cell malignancies
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Includes: Supplementary data
Journal Articles

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development

In Special Collection:
2020 Update on Experimental Hematology , Hematopoiesis and Leukemia
Jin Huk Choi, Xue Zhong, Zhao Zhang, Lijing Su, William McAlpine, Takuma Misawa, Tzu-Chieh Liao, Xiaoming Zhan, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Priscilla Anderton, Eva Marie Y. Moresco, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2020) 217 (4): e20190006.
https://doi.org/10.1084/jem.20190006
Published: 27 January 2020
View articletitled, Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development
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Includes: Supplementary data
Journal Articles

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR

In Special Collection:
JEM Immunology Collection 2021 , Inflammasome Signaling , Cytokines Collection 2020
Meng Deng, Haitao Guo, Jason W. Tam, Brandon M. Johnson, W. June Brickey, James S. New, Austin Lenox, Hexin Shi, Douglas T. Golenbock, Beverly H. Koller, Karen P. McKinnon, Bruce Beutler, Jenny P.-Y. Ting
Journal: Journal of Experimental Medicine
J Exp Med (2019) 216 (12): 2838–2853.
https://doi.org/10.1084/jem.20190111
Published: 26 October 2019
View articletitled, Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR
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Includes: Supplementary data
Journal Articles

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

Lei Sun, Zhengfan Jiang, Victoria A. Acosta-Rodriguez, Michael Berger, Xin Du, Jin Huk Choi, Jianhui Wang, Kuan-wen Wang, Gokhul K. Kilaru, Jennifer A. Mohawk, Jiexia Quan, Lindsay Scott, Sara Hildebrand, Xiaohong Li, Miao Tang, Xiaoming Zhan, Anne R. Murray, Diantha La Vine, Eva Marie Y. Moresco, Joseph S. Takahashi, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (11): 3263–3277.
https://doi.org/10.1084/jem.20161630
Published: 02 October 2017
View articletitled, HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections
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Includes: Supplementary data
Journal Articles

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Charlotte Viant, Sophie Guia, Robert J. Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T. Belz, Benjamin T. Kile, Andreas Strasser, Daniel Gray, Phillip D. Hodgkin, Bruce Beutler, Eric Vivier, Sophie Ugolini, Nicholas D. Huntington
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (2): 491–510.
https://doi.org/10.1084/jem.20160869
Published: 05 January 2017
View articletitled, Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival
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Journal Articles

Consequences of the recurrent MYD88L265P somatic mutation for B cell tolerance

James Q. Wang, Yogesh S. Jeelall, Bruce Beutler, Keisuke Horikawa, Christopher C. Goodnow
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (3): 413–426.
https://doi.org/10.1084/jem.20131424
Published: 17 February 2014
View articletitled, Consequences of the recurrent MYD88L265P somatic mutation for B cell tolerance
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Journal Articles

ZBTB1 is a determinant of lymphoid development

Owen M. Siggs, Xiaohong Li, Yu Xia, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2011) 209 (1): 19–27.
https://doi.org/10.1084/jem.20112084
Published: 26 December 2011
View articletitled, ZBTB1 is a determinant of lymphoid development
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Includes: Supplementary data
Journal Articles

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

Ryutaro Fukui, Shin-ichiroh Saitoh, Fumi Matsumoto, Hiroko Kozuka-Hata, Masaaki Oyama, Koichi Tabeta, Bruce Beutler, Kensuke Miyake
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (6): 1339–1350.
https://doi.org/10.1084/jem.20082316
Published: 18 May 2009
View articletitled, Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
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Includes: Supplementary data
Journal Articles

Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

Karine Crozat, Kasper Hoebe, Sophie Ugolini, Nancy A. Hong, Edith Janssen, Sophie Rutschmann, Suzanne Mudd, Sosathya Sovath, Eric Vivier, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (3): 737.
https://doi.org/10.1084/jem.20062447020108c
Published: 18 February 2008
View articletitled, Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
Open the PDF for Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis in another window
Journal Articles

Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

Karine Crozat, Kasper Hoebe, Sophie Ugolini, Nancy A. Hong, Edith Janssen, Sophie Rutschmann, Suzanne Mudd, Sosathya Sovath, Eric Vivier, Bruce Beutler
Journal: Journal of Experimental Medicine
J Exp Med (2007) 204 (4): 853–863.
https://doi.org/10.1084/jem.20062447
Published: 09 April 2007
View articletitled, Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
Open the PDF for Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis in another window
Includes: Supplementary data
Journal Articles

A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

Thomas R. Hawn, Annelies Verbon, Kamilla D. Lettinga, Lue Ping Zhao, Shuying Sue Li, Richard J. Laws, Shawn J. Skerrett, Bruce Beutler, Lea Schroeder, Alex Nachman, Adrian Ozinsky, Kelly D. Smith, Alan Aderem
Journal: Journal of Experimental Medicine
J Exp Med (2003) 198 (10): 1563–1572.
https://doi.org/10.1084/jem.20031220
Published: 17 November 2003
View articletitled, A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease
Open the PDF for A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease in another window