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A partial form of inherited human USP18 deficiency underlies infection and inflammation

In Special Collection:

Innate Immunity: From Basic Biology to Human Disease

J Exp Med (2022) 219 (4): e20211273.

DOI: https://doi.org/10.1084/jem.20211273

Published: 08 March 2022

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Includes: Supplementary data

Journal Articles

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Kerry L. Hilligan, Sivaranjani Namasivayam, Chad S. Clancy, Danielle O’Mard, Sandra D. Oland, Shelly J. Robertson, Paul J. Baker, Ehydel Castro, Nicole L. Garza, Bernard A.P. Lafont, Reed Johnson, Franca Ronchese, Katrin D. Mayer-Barber, Sonja M. Best, Alan Sher

J Exp Med (2021) 219 (2): e20211862.

DOI: https://doi.org/10.1084/jem.20211862

Published: 10 December 2021

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Includes: Supplementary data

Journal Articles

Sterilizing immunity: New opportunities for rational TB vaccine design

Alan Sher, Joanne L. Flynn

J Exp Med (2021) 218 (7): e20210454.

DOI: https://doi.org/10.1084/jem.20210454

Published: 26 May 2021

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Journal Articles

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

In Special Collection:

2019: The Year in Experimental Medicine , Innate Immune Sensors in Health and Disease

Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam, Nicolas Riteau, Olena Kamenyeva, Lara Mittereder, Katrin D. Mayer-Barber, Bruno B. Andrade, Alan Sher

J Exp Med (2019) 216 (3): 556–570.

DOI: https://doi.org/10.1084/jem.20181776

Published: 20 February 2019

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Includes: Supplementary data

Journal Articles

Transient T-bet expression functionally specifies a distinct T follicular helper subset

Difeng Fang, Kairong Cui, Kairui Mao, Gangqing Hu, Rao Li, Mingzhu Zheng, Nicolas Riteau, Steven L. Reiner, Alan Sher, Keji Zhao, Jinfang Zhu

J Exp Med (2018) 215 (11): 2705–2714.

DOI: https://doi.org/10.1084/jem.20180927

Published: 19 September 2018

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Includes: Supplementary data

Journal Articles

Type I interferons in tuberculosis: Foe and occasionally friend

In Special Collection:

Cytokines 2018 , JEM Reviews Collection

Lúcia Moreira-Teixeira, Katrin Mayer-Barber, Alan Sher, Anne O’Garra

J Exp Med (2018) 215 (5): 1273–1285.

DOI: https://doi.org/10.1084/jem.20180325

Published: 17 April 2018

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Journal Articles

Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes

David G. Kugler, Francis A. Flomerfelt, Diego L. Costa, Karen Laky, Olena Kamenyeva, Paul R. Mittelstadt, Ronald E. Gress, Stephan P. Rosshart, Barbara Rehermann, Jonathan D. Ashwell, Alan Sher, Dragana Jankovic

J Exp Med (2016) 213 (13): 3041–3056.

DOI: https://doi.org/10.1084/jem.20151636

Published: 14 November 2016

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Includes: Supplementary data

Journal Articles

CD4⁺ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

David G. Kugler, Paul R. Mittelstadt, Jonathan D. Ashwell, Alan Sher, Dragana Jankovic

J Exp Med (2013) 210 (10): 1919–1927.

DOI: https://doi.org/10.1084/jem.20122300

Published: 26 August 2013

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Journal Articles

Remembering Ralph Steinman

Jacques Banchereau, Fern Cohn, Kayo Inaba, Bill Muller, Ira Mellman, Carl Nathan, Michel Nussenzweig, Anne O’Garra, Bob Seder, Gerold Schuler, Alan Sher

J Exp Med (2011) 208 (12): 2343–2347.

DOI: https://doi.org/10.1084/jem.20112295

Published: 21 November 2011

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Journal Articles

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

Svenja Steinfelder, John F. Andersen, Jennifer L. Cannons, Carl G. Feng, Manju Joshi, Dennis Dwyer, Pat Caspar, Pamela L. Schwartzberg, Alan Sher, Dragana Jankovic

J Exp Med (2009) 206 (8): 1681–1690.

DOI: https://doi.org/10.1084/jem.20082462

Published: 27 July 2009

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Includes: Supplementary data

Journal Articles

Cholera toxin inhibits IL-12 production and CD8α⁺ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

Andrea la Sala, Jianping He, Leopoldo Laricchia-Robbio, Stefania Gorini, Akiko Iwasaki, Michael Braun, George S. Yap, Alan Sher, Keiko Ozato, Brian Kelsall

J Exp Med (2009) 206 (7): 1635.

DOI: https://doi.org/10.1084/jem.2008091262209c

Published: 29 June 2009

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Journal Articles

Cholera toxin inhibits IL-12 production and CD8α⁺ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

Andrea la Sala, Jianping He, Leopoldo Laricchia-Robbio, Stefania Gorini, Akiko Iwasaki, Michael Braun, George S. Yap, Alan Sher, Keiko Ozato, Brian Kelsall

J Exp Med (2009) 206 (6): 1227–1235.

DOI: https://doi.org/10.1084/jem.20080912

Published: 01 June 2009

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Includes: Supplementary data

Journal Articles

Host ER–parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii–infected dendritic cells

Romina S. Goldszmid, Isabelle Coppens, Avital Lev, Pat Caspar, Ira Mellman, Alan Sher

J Exp Med (2009) 206 (2): 399–410.

DOI: https://doi.org/10.1084/jem.20082108

Published: 19 January 2009

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Includes: Supplementary data

Journal Articles

Tpl2 kinase regulates T cell interferon-γ production and host resistance to Toxoplasma gondii

Wendy T. Watford, Bruce D. Hissong, Lydia R. Durant, Hidehiro Yamane, Linda M. Muul, Yuka Kanno, Cristina M. Tato, Haydeé L. Ramos, Alan E. Berger, Lisa Mielke, Marko Pesu, Benjamin Solomon, David M. Frucht, William E. Paul, Alan Sher, Dragana Jankovic, Philip N. Tsichlis, John J. O'Shea

J Exp Med (2008) 205 (12): 2803–2812.

DOI: https://doi.org/10.1084/jem.20081461

Published: 10 November 2008

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Includes: Supplementary data

Journal Articles

TAP-1 indirectly regulates CD4⁺ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-γ production

Romina S. Goldszmid, Andre Bafica, Dragana Jankovic, Carl G. Feng, Pat Caspar, Robin Winkler-Pickett, Giorgio Trinchieri, Alan Sher

J Exp Med (2007) 204 (11): 2591–2602.

DOI: https://doi.org/10.1084/jem.20070634

Published: 08 October 2007

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Includes: Supplementary data

Journal Articles

Conventional T-bet⁺Foxp3⁻ Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection

Dragana Jankovic, Marika C. Kullberg, Carl G. Feng, Romina S. Goldszmid, Carmen M. Collazo, Mark Wilson, Thomas A. Wynn, Masahito Kamanaka, Richard A. Flavell, Alan Sher

J Exp Med (2007) 204 (2): 273–283.

DOI: https://doi.org/10.1084/jem.20062175

Published: 05 February 2007

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Includes: Supplementary data

Journal Articles

IL-23 plays a key role in Helicobacter hepaticus–induced T cell–dependent colitis

Marika C. Kullberg, Dragana Jankovic, Carl G. Feng, Sophie Hue, Peter L. Gorelick, Brent S. McKenzie, Daniel J. Cua, Fiona Powrie, Allen W. Cheever, Kevin J. Maloy, Alan Sher

J Exp Med (2006) 203 (11): 2485–2494.

DOI: https://doi.org/10.1084/jem.20061082

Published: 09 October 2006

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Journal Articles

SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation

Jennifer L. Cannons, Li J. Yu, Dragana Jankovic, Shane Crotty, Reiko Horai, Martha Kirby, Stacie Anderson, Allen W. Cheever, Alan Sher, Pamela L. Schwartzberg

J Exp Med (2006) 203 (6): 1551–1565.

DOI: https://doi.org/10.1084/jem.20052097

Published: 05 June 2006

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Includes: Supplementary data

Journal Articles

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis

Andre Bafica, Charles A. Scanga, Carl G. Feng, Cynthia Leifer, Allen Cheever, Alan Sher

J Exp Med (2005) 202 (12): 1715–1724.

DOI: https://doi.org/10.1084/jem.20051782

Published: 19 December 2005

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Includes: Supplementary data

Journal Articles

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

Makoto Arita, Francesca Bianchini, Julio Aliberti, Alan Sher, Nan Chiang, Song Hong, Rong Yang, Nicos A. Petasis, Charles N. Serhan

J Exp Med (2005) 201 (5): 713–722.

DOI: https://doi.org/10.1084/jem.20042031

Published: 07 March 2005

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Includes: Supplementary data

NARROW

A partial form of inherited human USP18 deficiency underlies infection and inflammation

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Sterilizing immunity: New opportunities for rational TB vaccine design

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

Transient T-bet expression functionally specifies a distinct T follicular helper subset

Type I interferons in tuberculosis: Foe and occasionally friend

Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes

CD4⁺ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

Remembering Ralph Steinman

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

Cholera toxin inhibits IL-12 production and CD8α⁺ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

Cholera toxin inhibits IL-12 production and CD8α⁺ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

Host ER–parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii–infected dendritic cells

Tpl2 kinase regulates T cell interferon-γ production and host resistance to Toxoplasma gondii

TAP-1 indirectly regulates CD4⁺ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-γ production

Conventional T-bet⁺Foxp3⁻ Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection

IL-23 plays a key role in Helicobacter hepaticus–induced T cell–dependent colitis

SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

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