Article
Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses
Saad et al. show that colorectal tumors with distinct metastatic potential trigger divergent early T cell responses. Nonmetastatic tumors recruit cytotoxic, Th1-like T cells that suppress growth, whereas pro-metastatic tumors downregulate MHCII and induce a hypoactivated, naïve-like state, enabling immune escape before metastatic dissemination.
