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    Cover Image

    issue cover

    ON THE COVER
    Das et al. show that lymphatic sinuses control tumor cell entry into the lymph node. CCL1 expression in the lymph node attracts CCR8+ malignant melanoma cells, and tumor cell metastasis is inhibited by blocking CCR8–CCL1 signaling. The cover image is a color-modified SEM micrograph depicting lymph node architecture of the subcapsular sinus. Artwork by Joshua Graver (joshuagraver@mac.com).
    See page 1509

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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Brief Definitive Report

The specificity of H1N1 antibody responses can be shifted to epitopes near the HA receptor–binding domain after sequential infections with viral strains that share homology in this region.

Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.

Article

Blocking CCR8 inhibits entry of metastases from the collecting lymphatic vessel into the lymph node.

BRCA1 deficiency results in impaired Nrf2-mediated antioxidant responses followed by cell death, with estradiol rescuing the effect by inducing Nrf2 stabilization.

miR-223 is upregulated by the transcription factor TAL1 in human T-ALL cells and suppress the FBXW7 tumor suppressor.

Loss of GGPPS from childhood mumps infection or deletion in mice results in constitutively activated MAPK and NF-kB signaling that induces spermatogonium apoptosis, macrophage invasion into seminiferous tubules, and sterility.

Ubiquitin-specific protease 18 inhibits ubiquitination of TAK1–TAB complexes to restrict IL-2 production and promote Th17 differentiation and autoimmune responses.

CD40+ DCs interact with CD154+CD4+ T cells to abrogate T reg cell–mediated suppression of influenza-specific CD8+ T cells.

The transcription factor DEC1 is induced by CD28 ligation and is required for optimal CD4+ T cell responses and the development of EAE.

The kinase MK5 phosphorylates and activates Foxo1 at serine 215, and this modification is required for Foxo1 to induce Rag transcription.

Acute Plasmodium infections in humans result in dendritic cell dysfunction and apoptosis caused in part by elevated levels of IL-10.

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