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Editorial

Unpleasant surprises: how the Introduction has wandered into the Discussion

William A. Wells
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In This Issue

Tough antigens trigger immunity

Heather L. Van Epps
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Complement complicates pregnancies

Heather L. Van Epps
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Desperately seeking synapses

Heather L. Van Epps
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Can DCs forecast atherosclerosis?

Heather L. Van Epps
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Sympathy for t-PA

Heather L. Van Epps
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From the Archive

Escape from fatal fusion

Ruth Williams
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Brief Definitive Report

Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis

Lélia Delamarre,Rachael Couture,Ira Mellman,E. Sergio Trombetta
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The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine

Matthias Mueller,Igor Cima,Mario Noti,Andrea Fuhrer,Sabine Jakob,Laurent Dubuquoy,Kristina Schoonjans,Thomas Brunner
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Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

Yun M. Ling,Michael H. Shaw,Carol Ayala,Isabelle Coppens,Gregory A. Taylor,David J.P. Ferguson,George S. Yap
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Article

Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis

Jenny Jongstra-Bilen,Mehran Haidari,Su-Ning Zhu,Mian Chen,Daipayan Guha,Myron I. Cybulsky
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The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2−/− ung−/− mice

Kanmin Xue,Cristina Rada,Michael S. Neuberger
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In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain

Carlos Barcia,Clare E. Thomas,James F. Curtin,Gwendalyn D. King,Kolja Wawrowsky,Marianela Candolfi,Wei-Dong Xiong,Chunyan Liu,Kurt Kroeger,Olivier Boyer,Jerzy Kupiec-Weglinski,David Klatzmann,Maria G. Castro,Pedro R. Lowenstein
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Carbon monoxide reverses established pulmonary hypertension

Brian S. Zuckerbraun,Beek Yoke Chin,Barbara Wegiel,Timothy R. Billiar,Eva Czsimadia,Jayashree Rao,Larissa Shimoda,Emeka Ifedigbo,Shin Kanno,Leo E. Otterbein
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A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant

Lindzy D. Friend,Dulari D. Shah,Christine Deppong,Joseph Lin,Traci L. Bricker,Twyla I. Juehne,Christine M. Rose,Jonathan M. Green
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Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response

Martin Prlic,Gabriela Hernandez-Hoyos,Michael J. Bevan
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Elimination of chronic viral infection by blocking CD27 signaling

Matthias Matter,Bernhard Odermatt,Hideo Yagita,Jean-Marc Nuoffer,Adrian F. Ochsenbein
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Selective dysregulation of the FcγIIB receptor on memory B cells in SLE

Meggan Mackay,Anfisa Stanevsky,Tao Wang,Cynthia Aranow,Margaret Li,Scott Koenig,Jeffrey V. Ravetch,Betty Diamond
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Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Guillermina Girardi,Dmitry Yarilin,Joshua M. Thurman,V. Michael Holers,Jane E. Salmon
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NF-κB translocation prevents host cell death after low-dose challenge by Legionella pneumophila

Vicki P. Losick,Ralph R. Isberg
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The plasminogen activator system modulates sympathetic nerve function

Ulrich Schaefer,Takuji Machida,Sandra Vorlova,Sidney Strickland,Roberto Levi
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A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

Jennifer M. Burns,Bretton C. Summers,Yu Wang,Anita Melikian,Rob Berahovich,Zhenhua Miao,Mark E. T. Penfold,Mary Jean Sunshine,Dan R. Littman,Calvin J. Kuo,Kevin Wei,Brian E. McMaster,Kim Wright,Maureen C. Howard,Thomas J. Schall
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Of Interest in the JCB

ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

Andreas W. Jehle,Shyra J. Gardai,Suzhao Li,Patrick Linsel-Nitschke,Konosuke Morimoto,William J. Janssen,R. William Vandivier,Nan Wang,Steven Greenberg,Benjamin M. Dale,Chunbo Qin,Peter M. Henson,Alan R. Tall
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Of Interest in the JCB

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Yuya Kunisaki,Akihiko Nishikimi,Yoshihiko Tanaka,Ryosuke Takii,Mayuko Noda,Ayumi Inayoshi,Ken-ichi Watanabe,Fumiyuki Sanematsu,Takehiko Sasazuki,Takehiko Sasaki,Yoshinori Fukui
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Of Interest in the JCB

Specificity in reactive oxidant signaling: think globally, act locally

Lance S. Terada
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Correction

Correction

Daniel B. Stetson,Ruslan Medzhitov
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