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Volume 203, Issue 9

4 September 2006

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Cover Image

Cover Image

ON THE COVER
Artwork (cut Coloraid paper on paper) by New York artist Rachel Urkowitz (email: rachelurk@earthlink.net). Image shows an in vivo immunological synapse formed between a cytotoxic T cell and a virus-infected brain cell. Related article by Barcia et al.
See page 2095
Table of Contents
Editorial Board

ISSN 0022-1007

EISSN 1540-9538

In this Issue

Editorial
In This Issue
From the Archive
Brief Definitive Report
Article
Correction
In This Issue
Article

Editorial

Unpleasant surprises: how the Introduction has wandered into the Discussion

William A. Wells

In This Issue

Tough antigens trigger immunity

Heather L. Van Epps

Complement complicates pregnancies

Heather L. Van Epps

From the Archive

Escape from fatal fusion

Ruth Williams

Brief Definitive Report

Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis

Lélia Delamarre,Rachael Couture,Ira Mellman,E. Sergio Trombetta

The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine

Matthias Mueller,Igor Cima,Mario Noti,Andrea Fuhrer,Sabine Jakob,Laurent Dubuquoy,Kristina Schoonjans,Thomas Brunner

Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

Yun M. Ling,Michael H. Shaw,Carol Ayala,Isabelle Coppens,Gregory A. Taylor,David J.P. Ferguson,George S. Yap

Article

Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis

Jenny Jongstra-Bilen,Mehran Haidari,Su-Ning Zhu,Mian Chen,Daipayan Guha,Myron I. Cybulsky

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2^−/−ung^−/− mice

Kanmin Xue,Cristina Rada,Michael S. Neuberger

In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain

Carlos Barcia,Clare E. Thomas,James F. Curtin,Gwendalyn D. King,Kolja Wawrowsky,Marianela Candolfi,Wei-Dong Xiong,Chunyan Liu,Kurt Kroeger,Olivier Boyer,Jerzy Kupiec-Weglinski,David Klatzmann,Maria G. Castro,Pedro R. Lowenstein

Carbon monoxide reverses established pulmonary hypertension

Brian S. Zuckerbraun,Beek Yoke Chin,Barbara Wegiel,Timothy R. Billiar,Eva Czsimadia,Jayashree Rao,Larissa Shimoda,Emeka Ifedigbo,Shin Kanno,Leo E. Otterbein

A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant

Lindzy D. Friend,Dulari D. Shah,Christine Deppong,Joseph Lin,Traci L. Bricker,Twyla I. Juehne,Christine M. Rose,Jonathan M. Green

Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8⁺ T cell response

Martin Prlic,Gabriela Hernandez-Hoyos,Michael J. Bevan

Elimination of chronic viral infection by blocking CD27 signaling

Matthias Matter,Bernhard Odermatt,Hideo Yagita,Jean-Marc Nuoffer,Adrian F. Ochsenbein

Selective dysregulation of the FcγIIB receptor on memory B cells in SLE

Meggan Mackay,Anfisa Stanevsky,Tao Wang,Cynthia Aranow,Margaret Li,Scott Koenig,Jeffrey V. Ravetch,Betty Diamond

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Guillermina Girardi,Dmitry Yarilin,Joshua M. Thurman,V. Michael Holers,Jane E. Salmon

NF-κB translocation prevents host cell death after low-dose challenge by Legionella pneumophila

Vicki P. Losick,Ralph R. Isberg

The plasminogen activator system modulates sympathetic nerve function

Ulrich Schaefer,Takuji Machida,Sandra Vorlova,Sidney Strickland,Roberto Levi

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

Jennifer M. Burns,Bretton C. Summers,Yu Wang,Anita Melikian,Rob Berahovich,Zhenhua Miao,Mark E. T. Penfold,Mary Jean Sunshine,Dan R. Littman,Calvin J. Kuo,Kevin Wei,Brian E. McMaster,Kim Wright,Maureen C. Howard,Thomas J. Schall

Correction

Correction

Daniel B. Stetson,Ruslan Medzhitov

In This Issue

Desperately seeking synapses

Heather L. Van Epps

Can DCs forecast atherosclerosis?

Heather L. Van Epps

Sympathy for t-PA

Heather L. Van Epps

Article

ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

Andreas W. Jehle,Shyra J. Gardai,Suzhao Li,Patrick Linsel-Nitschke,Konosuke Morimoto,William J. Janssen,R. William Vandivier,Nan Wang,Steven Greenberg,Benjamin M. Dale,Chunbo Qin,Peter M. Henson,Alan R. Tall

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Yuya Kunisaki,Akihiko Nishikimi,Yoshihiko Tanaka,Ryosuke Takii,Mayuko Noda,Ayumi Inayoshi,Ken-ichi Watanabe,Fumiyuki Sanematsu,Takehiko Sasazuki,Takehiko Sasaki,Yoshinori Fukui

Specificity in reactive oxidant signaling: think globally, act locally

Lance S. Terada

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Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8⁺ T cells

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

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