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    Actin-rich membrane cups around FcγR-bound particles in macrophages derived from mice genetically deficient for Syk tyrosine kinase. Polymerized actin structures (green) form around FcγR-bound particles and are indistinguishable from those formed in wild-type cells. However, Syk-deficient cells are unable to affect closure of these actin cups. Syk-deficient macrophages are defective in other FcγR-induced signaling events as well. See related article in this issue by Crowley et al., pp. 1027–1039.

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ISSN 0022-1007
EISSN 1540-9538
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