1. A vaccine prepared from partially defatted bovine tubercle bacilli influenced favorably the survival time after inoculation with living virulent bovine tubercle bacilli.
2. Accompanying this increased resistance was a sustained lymphocytosis in the vaccinated animals.
3. The vaccine induced a transitory anemia and leucopenia.
4. A similar preparation of partially defatted human tubercle bacilli possessed the power to sensitize guinea pigs to tuberculo-protein.