An erythema dose of x-rays given direct to the exposed subcutaneous tissue and muscle greatly diminishes the susceptibility of the exposed area to transplanted cancer. The same dose given over the intact skin does not affect the resisting power of the underlying subcutaneous tissue.

Histological examination shows that a few days after the exposure of the subcutaneous tissue there is a lymphoid infiltration of this tissue, which infiltration sometimes includes the muscle layers as well.

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