STUDIES ON X-RAY EFFECTS : IV. DIRECT ACTION OF X-RAYS ON TRANSPLANTABLE CANCERS OF MICE.

These experiments indicate that the direct action of x-rays in more powerful doses than can be applied therapeutically is somewhat injurious to tumor cells, but by no means destroys them. Experiment 1 also indicates that the cancer cells establish a resistance to the x-rays after repeated doses. This harmonizes with the experience of clinicians who have succeeded in checking cancerous growths for some time but reach a point where no response can be effected by repeated doses. The rays of low penetration used in Experiment 2 are apparently more harmful to tumor cells than the penetrating rays used in Experiment 1.