The role of T cells expressing specific V beta elements was examined in the regulation of allergen-specific immunoglobulin (Ig)E production and airways responsiveness (AR). In BALB/c mice, inhalation of the allergen ovalbumin (OVA) induced an IgE anti-OVA response, immediate cutaneous reactivity, and increased AR. These results were associated with an expansion of V beta 8.1/8.2 T cells in local draining lymph nodes of the airways and the lung. Transfer of V beta 8.1/8.2 T cells from sensitized mice stimulated an IgE anti-OVA response, immediate cutaneous hypersensitivity, and increased AR in naive syngeneic recipients. In contrast, OVA-reactive V beta 2 T cells inhibited these effects. These data demonstrate for the first time that T cells with different V beta specificities play a critical role in the in vivo regulation of allergen-specific IgE production and AR.
T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo.
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H Renz, K Bradley, J Saloga, J Loader, G L Larsen, E W Gelfand; T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo.. J Exp Med 1 April 1993; 177 (4): 1175–1180. doi: https://doi.org/10.1084/jem.177.4.1175
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