To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL-6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".
DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.
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T Blankenstein, Z H Qin, W Q Li, T Diamantstein; DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.. J Exp Med 1 March 1990; 171 (3): 965–970. doi: https://doi.org/10.1084/jem.171.3.965
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