Epidermal regeneration depends on mitosis and migration of keratinocytes. Epidermal growth factor is known to stimulate growth of keratinocytes in vitro, thus it might be expected to promote wound healing. The results of this study show that topical application of biosynthetic human epidermal growth factor accelerates epidermal regeneration in split-thickness wounds and partial-thickness burns. The significant enhancement of epidermal regeneration suggests the potential for clinical use of epidermal growth factor for accelerating healing of burns, wounds from trauma, diabetic ulcers, skin graft donor sites, and others.
Enhancement of epidermal regeneration by biosynthetic epidermal growth factor.
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G L Brown, L Curtsinger, J R Brightwell, D M Ackerman, G R Tobin, H C Polk, C George-Nascimento, P Valenzuela, G S Schultz; Enhancement of epidermal regeneration by biosynthetic epidermal growth factor.. J Exp Med 1 May 1986; 163 (5): 1319–1324. doi: https://doi.org/10.1084/jem.163.5.1319
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