gamma gene rearrangements similar to those described for cytotoxic T cell lines are found in L3T4+, autoreactive, or KLH-specific cloned helper T cell lines. High levels of gamma RNA transcripts were, in addition, detected in four out of five L3T4+, class II MHC-specific, autoreactive T cell clones, and in at least one of three KLH-specific, class II MHC-restricted clones. This contrasts with previously reported (9) expression of gamma RNA in only 1 of 11 antigen-specific helper T cell lines.
Article| May 01 1986
Gamma gene rearrangement and expression in autoreactive helper T cells.
T W Mak
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1986) 163 (5): 1314–1318.
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M Zauderer, A Iwamoto, T W Mak; Gamma gene rearrangement and expression in autoreactive helper T cells.. J Exp Med 1 May 1986; 163 (5): 1314–1318. doi: https://doi.org/10.1084/jem.163.5.1314
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