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Volume 162, Issue 1
1 July 1985
Journal of Experimental Medicine Cover Image for Volume 162, Issue 1
Article| July 01 1985

Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.

W C Greene,
W C Greene
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R J Robb,
R J Robb
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P B Svetlik,
P B Svetlik
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C M Rusk,
C M Rusk
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J M Depper,
J M Depper
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W J Leonard
W J Leonard
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Author and Article Information
W C Greene
R J Robb
P B Svetlik
C M Rusk
J M Depper
W J Leonard
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1985) 162 (1): 363–368.
https://doi.org/10.1084/jem.162.1.363

Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.

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