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Volume 162, Issue 1
1 July 1985
Journal of Experimental Medicine Cover Image for Volume 162, Issue 1
Article| July 01 1985

Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.

R L Kirkman,
R L Kirkman
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L V Barrett,
L V Barrett
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G N Gaulton,
G N Gaulton
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V E Kelley,
V E Kelley
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A Ythier,
A Ythier
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T B Strom
T B Strom
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Author and Article Information
R L Kirkman
L V Barrett
G N Gaulton
V E Kelley
A Ythier
T B Strom
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1985) 162 (1): 358–362.
https://doi.org/10.1084/jem.162.1.358

Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.

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