Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.
Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.
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R L Kirkman, L V Barrett, G N Gaulton, V E Kelley, A Ythier, T B Strom; Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.. J Exp Med 1 July 1985; 162 (1): 358–362. doi: https://doi.org/10.1084/jem.162.1.358
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