Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.
Activation of human macrophages. Comparison of other cytokines with interferon-gamma.
C F Nathan, T J Prendergast, M E Wiebe, E R Stanley, E Platzer, H G Remold, K Welte, B Y Rubin, H W Murray; Activation of human macrophages. Comparison of other cytokines with interferon-gamma.. J Exp Med 1 August 1984; 160 (2): 600–605. doi: https://doi.org/10.1084/jem.160.2.600
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