The genetic requirements of carrier recognition were examined in the priming and elicitation of hapten specific, T-cell mediated, delayed-type hypersensitivity (DTH) responses. It was shown that nitrophenyl acetyl-poly-(L-glu56-L-lys35-L-phe9) (NP-GLO) could prime for NP responses only in strains of mice which are Ir gene responders to GLO. In contrast to this requirement, NO-GLO could elicit an NP-specific response in NP-bovine gamma globulin primed mice, even in GLO nonresponder strains. Furthermore, the nonimmunogenic molecule, NP-GL, could elicit an NP-specific DTH response in animals primed with NP on an immunogenic carrier.
Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses.
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J Z Weinberger, B Benacerraf, M E Dorf; Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses.. J Exp Med 1 November 1979; 150 (5): 1255–1259. doi: https://doi.org/10.1084/jem.150.5.1255
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