Subdural inoculation of tubercle bacilli of established virulence for guinea pigs and rabbits, produces in the dog a tuberculous meningitis, followed by paralysis and death. When suspensions of canine leucocytes are injected subdurally, following such inoculations there occurs uniformly a delay in the development of the paralysis and a prolongation of the life of the treated animal. In dogs inoculated with small doses of tubercle bacilli of low virulence, the development of paralysis has been prevented by this means for periods of seven months (up to the present date), while the untreated animals injected with the same cultures have all developed paralytic symptoms within a period of about four weeks.
Article| January 01 1912
THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS
Wilfred H. Manwaring
From the Laboratories of The Rockefeller Institute for Medical Research, New York.
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Wilfred H. Manwaring; THE EFFECTS OF SUBDURAL INJECTIONS OF LEUCOCYTES ON THE DEVELOPMENT AND COURSE OF EXPERIMENTAL TUBERCULOUS MENINGITIS . J Exp Med 1 January 1912; 15 (1): 1–13. doi: https://doi.org/10.1084/jem.15.1.1
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