STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR

Schimpl , A.; Wecker , E.

doi:10.1084/jem.137.2.547

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Brief Definitive Report| February 01 1973

STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR

A. Schimpl,

A. Schimpl

From the Institute of Virology, Würzburg, West Germany

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E. Wecker

From the Institute of Virology, Würzburg, West Germany

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Author and Article Information

A. Schimpl

From the Institute of Virology, Würzburg, West Germany

E. Wecker

From the Institute of Virology, Würzburg, West Germany

Received: October 30 1972

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1973

J Exp Med (1973) 137 (2): 547–552.

https://doi.org/10.1084/jem.137.2.547

A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.

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