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Volume 133, Issue 4
1 April 1971
Journal of Experimental Medicine Cover Image for Volume 133, Issue 4
Article| April 01 1971

IGE AND IGGA ANTIBODY-MEDIATED RELEASE OF HISTAMINE FROM RAT PERITONEAL CELLS : I. OPTIMUM CONDITIONS FOR IN VITRO PREPARATION OF TARGET CELLS WITH ANTIBODY AND CHALLENGE WITH ANTIGEN

Michael K. Bach,
Michael K. Bach
From the Department of Medicine, Robert B. Brigham Hospital, the Clinical Immunology and Arthritis Units, Department of Medicine, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02120
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Kurt J. Bloch,
Kurt J. Bloch
From the Department of Medicine, Robert B. Brigham Hospital, the Clinical Immunology and Arthritis Units, Department of Medicine, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02120
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K. Frank Austen
K. Frank Austen
From the Department of Medicine, Robert B. Brigham Hospital, the Clinical Immunology and Arthritis Units, Department of Medicine, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02120
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Author and Article Information
Michael K. Bach
From the Department of Medicine, Robert B. Brigham Hospital, the Clinical Immunology and Arthritis Units, Department of Medicine, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02120
Kurt J. Bloch
From the Department of Medicine, Robert B. Brigham Hospital, the Clinical Immunology and Arthritis Units, Department of Medicine, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02120
K. Frank Austen
From the Department of Medicine, Robert B. Brigham Hospital, the Clinical Immunology and Arthritis Units, Department of Medicine, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02120
Received: November 04 1970
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 133 (4): 752–771.
https://doi.org/10.1084/jem.133.4.752
Article history
Received:
November 04 1970

The optimum conditions for antigen-induced release of histamine in the rat IgE and IgGa antibody-mediated systems were studied in vitro. The IgE antibody-mediated reaction could be separated into two steps: preparation of target cells with antibody and challenge with antigen. The optimal conditions for these two steps were distinctly different. Release of histamine by IgGa antibody and antigen could not be separated into two steps, and the optimal conditions for the total reaction were identical to those of the antigen challenge step of the IgE antibody-mediated system.

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Copyright © 1971 by The Rockefeller University Press
1971
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