Outbred Hartley strain guinea pigs capable of responding immunologically to 2,4-dinitrophenylated poly-L-lysine were shown to display a histocompatibility specificity in common with inbred strain 2 guinea pigs. This histocompatibility specificity was not detected in guinea pigs unable to respond immunologically to DNP-PLL. The result suggests that the poly-L-lysine specific immune response gene is very closely linked or even identical with a gene determining a major histocompatibility antigen in guinea pigs.
HISTOCOMPATIBILITY TYPE AND IMMUNE RESPONSIVENESS IN RANDOM BRED HARTLEY STRAIN GUINEA PIGS
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William John Martin, Leonard Ellman, Ira Green, Baruj Benacerraf; HISTOCOMPATIBILITY TYPE AND IMMUNE RESPONSIVENESS IN RANDOM BRED HARTLEY STRAIN GUINEA PIGS . J Exp Med 1 December 1970; 132 (6): 1259–1266. doi: https://doi.org/10.1084/jem.132.6.1259
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