Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of γ-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human γ-globulin showed that the capacity of the virus-infected animal to produce anti-human γ-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.
ELEVATED γ-GLOBULIN AND INCREASED ANTIBODY PRODUCTION IN MICE INFECTED WITH LACTIC DEHYDROGENASE VIRUS
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Abner Louis Notkins, Stephan E. Mergenhagen, Anthony A. Rizzo, Christina Scheele, Thomas A. Waldmann; ELEVATED γ-GLOBULIN AND INCREASED ANTIBODY PRODUCTION IN MICE INFECTED WITH LACTIC DEHYDROGENASE VIRUS . J Exp Med 1 February 1966; 123 (2): 347–364. doi: https://doi.org/10.1084/jem.123.2.347
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