Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle hemoglobin. The rapid growth of these crystals causing tenting of the cell membrane is responsible for the bizarre distortion of the erythrocytes and presumably for the disease itself.
Article| February 01 1966
THE STATE OF HEMOGLOBIN IN SICKLED ERYTHROCYTES
Chandler A. Stetson, Jr.
From the Department of Pathology, New York University School of Medicine, New York
Received: September 10 1965
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright © 1966 by The Rockefeller University Press
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Chandler A. Stetson; THE STATE OF HEMOGLOBIN IN SICKLED ERYTHROCYTES . J Exp Med 1 February 1966; 123 (2): 341–346. doi: https://doi.org/10.1084/jem.123.2.341
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