Decrease in the protease activity of the culture fluid observed at later stages of the antigen-antibody reaction is believed to be due to the release of an inhibitor by the cells. The inhibitor was submitted to partial purification: it is heat-stable, non-precipitated by trichloracetic acid and non-dialyzable. It inhibits certain cellular and tissue proteases and papain but is inactive against trypsin. It is suggested that the balance between protease and anti-protease released may determine the intensity, extent, and duration of certain sensitization phenomena.
BIOCHEMICAL STUDY OF CELLULAR ANTIGEN-ANTIBODY REACTION IN TISSUE CULTURE : II. RELEASE OF A PROTEASE INHIBITOR
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Akira Tokuda, Hideo Hayashi, Kinishiro Matsuba; BIOCHEMICAL STUDY OF CELLULAR ANTIGEN-ANTIBODY REACTION IN TISSUE CULTURE : II. RELEASE OF A PROTEASE INHIBITOR . J Exp Med 1 August 1960; 112 (2): 249–255. doi: https://doi.org/10.1084/jem.112.2.249
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