The injection of podophyllotoxin, colchicine, and a nitrogen mustard derivative, methyl-bis(ß-chloroethyl)amine, into normal animals causes a reduction of the respiration of the lymphatic tissues, spleen, and/or thymus. No effect was demonstrable on kidney, a representative tissue of non-lymphatic origin.
The degree of inhibition was considerably less in suprarenalectomized animals, suggesting that the inhibition is mediated by the suprarenal gland.
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Copyright, 1950, by The Rockefeller Institute for Medical Research New York
1950
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