Of all the drugs thus far used in testing the resistance of suprarenalectomized rats, histamine has been found to be the most satisfactory. It is a readily obtainable and comparatively stable drug, producing characteristic symptoms. Its M.L.D. for a given strain of rats can be established within narrow limits, and the difference between the M.L.D. for normal and suprarenalectomized rats is comparatively great (1:20).

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