NEPHROTOXIC NEPHRITIS IN RATS EVIDENCE FOR THE GLOMERULAR ORIGIN OF THE KIDNEY ANTIGEN

Solomon , David H.; Gardella , Joseph W.; Fanger , Herbert; Dethier , Frances M.; Ferrebee , Joseph W.

doi:10.1084/jem.90.3.267

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Article| September 01 1949

NEPHROTOXIC NEPHRITIS IN RATS : EVIDENCE FOR THE GLOMERULAR ORIGIN OF THE KIDNEY ANTIGEN

David H. Solomon,

David H. Solomon

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

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Joseph W. Gardella,

Joseph W. Gardella

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

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Herbert Fanger,

Herbert Fanger

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

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Frances M. Dethier,

Frances M. Dethier

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

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Joseph W. Ferrebee

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

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Author and Article Information

David H. Solomon

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

Joseph W. Gardella

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

Herbert Fanger

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

Frances M. Dethier

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

Joseph W. Ferrebee

From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

Received: May 31 1949

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1949, by The Rockefeller Institute for Medical Research New York

1949

J Exp Med (1949) 90 (3): 267–272.

https://doi.org/10.1084/jem.90.3.267

Nephrotoxic anti-rat kidney sera were produced in rabbits by intraperitoneal injection of suspensions of blood-free rat kidney. The nephrotoxin of these sera could be removed by adsorption with saline suspensions of finely ground rat glomeruli, but not by adsorption with other portions of rat kidney or by adsorption with several other rat tissues. It was concluded that nephrotoxic sera of this type react primarily with glomerular tissue and, by inference, that the antigen essential for the production of these anti-kidney sera was of glomerular origin.

The observations are consistent with Pressman's (15, 16) demonstration that anti-mouse kidney sera labeled with radioiodine localize primarily in glomeruli.

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Copyright, 1949, by The Rockefeller Institute for Medical Research New York

1949

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