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A saline extract of perfused rat kidney administered intravenously to rats immediately before injecting an anti-rat-kidney serum, by the same route, prevents renal damage. A preliminary injection of physiological salt solution or of an extract of perfused rat liver has no preventive effect.
These findings are a further indication that the nephrotoxic effect induced by anti-kidney serum is dependent upon a relatively organ specific antibody, nephrotoxin.
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Copyright, 1937, by The Rockefeller Institute for Medical Research New York
1937
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