TH17 cells thrive and react to the OVA antigen in mice lacking CD11b.
According to dogma, APCs that have only few costimulatory receptors dampen immunity. These APCs can't give T cells the stimulatory boost they need to become offensive. But some APCs with lots of costimulatory receptors can somehow still keep T cells in low gear.
One APC receptor that might direct this alternative pathway, the authors hypothesized, is CD11b. Mice need this integrin to remove neutrophils and macrophages from infection sites and subdue...
The Rockefeller University Press
2007
The Rockefeller University Press
2007
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