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Volume 204, Issue 7

9 July 2007

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ON THE COVER
Image shows a degenerated Dicerdeficient neuron. The absence of miRNA leads to a slow degeneration of cerebellar neurons in mice. Related article by Schaefer et al.
See page 1553
Table of Contents
Editorial Board

ISSN 0022-1007

EISSN 1540-9538

In this Issue

Editorial
In This Issue
From the Archive
Brief Definitive Report
Article
Correction

Editorial

How the rich get richer

Mike Rossner,Ira Mellman

View Articletitled, How the rich get richer

In This Issue

CD11b tunes tolerance

Hema Bashyam

View Articletitled, CD11b tunes tolerance

Keeping score of antigraft T cells

Hema Bashyam

View Articletitled, Keeping score of antigraft T cells

AID overwhelms Polβ in class-switching B cells

Hema Bashyam

View Articletitled, AID overwhelms Polβ in class-switching B cells

Neurons need miRNA to survive

Hema Bashyam

View Articletitled, Neurons need miRNA to survive

Antitumor drug sends new signals

Hema Bashyam

View Articletitled, Antitumor drug sends new signals

From the Archive

Lewis Dahl and the genetics of salt-induced hypertension

Hema Bashyam

View Articletitled, Lewis Dahl and the genetics of salt-induced hypertension

Brief Definitive Report

Interleukin 25 promotes the initiation of proallergic type 2 responses

Pornpimon Angkasekwinai,Heon Park,Yui-Hsi Wang,Yi-Hong Wang,Seon Hee Chang,David B. Corry,Yong-Jun Liu,Zhou Zhu,Chen Dong

View Articletitled, Interleukin 25 promotes the initiation of proallergic type 2 responses

CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

Driss Ehirchiou,Ying Xiong,Guangwu Xu,Wanjun Chen,Yufang Shi,Li Zhang

View Articletitled, CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

CD8⁻ DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

Dimitris Skokos,Michel C. Nussenzweig

View Articletitled, CD8− DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

Expansion and tissue infiltration of an allospecific CD4⁺CD25⁺CD45RO⁺IL-7Rα^high cell population in solid organ transplant recipients

Laura Codarri,Laure Vallotton,Donatella Ciuffreda,Jean-Pierre Venetz,Miguel Garcia,Karine Hadaya,Leo Buhler,Samuel Rotman,Manuel Pascual,Giuseppe Pantaleo

View Articletitled, Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Rαhigh cell population in solid organ transplant recipients

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

Hyoung-Pyo Kim,Warren J. Leonard

View Articletitled, CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

Cerebellar neurodegeneration in the absence of microRNAs

Anne Schaefer,Dónal O'Carroll,Chan Lek Tan,Dean Hillman,Mutsuyuki Sugimori,Rodolfo Llinas,Paul Greengard

View Articletitled, Cerebellar neurodegeneration in the absence of microRNAs

Article

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

Zachary J. Roberts,Nadege Goutagny,Pin-Yu Perera,Hiroki Kato,Himanshu Kumar,Taro Kawai,Shizuo Akira,Ram Savan,David van Echo,Katherine A. Fitzgerald,Howard A. Young,Lai-Ming Ching,Stefanie N. Vogel

View Articletitled, The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets

Ronit Pasvolsky,Sara W. Feigelson,Sara Sebnem Kilic,Amos J. Simon,Guy Tal-Lapidot,Valentin Grabovsky,Jill R. Crittenden,Ninette Amariglio,Michal Safran,Ann M. Graybiel,Gideon Rechavi,Shifra Ben-Dor,Amos Etzioni,Ronen Alon

View Articletitled, A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

Maxime Hervé,Isabelle Isnardi,Yen-shing Ng,James B. Bussel,Hans D. Ochs,Charlotte Cunningham-Rundles,Eric Meffre

View Articletitled, CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis

Christoph Anthoni,Janice Russell,Katherine C. Wood,Karen Y. Stokes,Thorsten Vowinkel,Daniel Kirchhofer,D. Neil Granger

View Articletitled, Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis

Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells

Cindy G. Leung,Yanfei Xu,Bretton Mularski,Hui Liu,Sandeep Gurbuxani,John D. Crispino

View Articletitled, Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification

Kozo Morita,Takeshi Miyamoto,Nobuyuki Fujita,Yoshiaki Kubota,Keisuke Ito,Keiyo Takubo,Kana Miyamoto,Ken Ninomiya,Toru Suzuki,Ryotaro Iwasaki,Mitsuru Yagi,Hironari Takaishi,Yoshiaki Toyama,Toshio Suda

View Articletitled, Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification

Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8⁺ T cells

Hirokazu Hikono,Jacob E. Kohlmeier,Shiki Takamura,Susan T. Wittmer,Alan D. Roberts,David L. Woodland

View Articletitled, Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8+ T cells

MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation

Magdalena M. Gorska,Qiaoling Liang,Susan J. Stafford,Nicolas Goplen,Nilesh Dharajiya,Lei Guo,Sanjiv Sur,Matthias Gaestel,Rafeul Alam

View Articletitled, MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation

Notch–RBP-J signaling controls the homeostasis of CD8⁻ dendritic cells in the spleen

Michele L. Caton,Matthew R. Smith-Raska,Boris Reizis

View Articletitled, Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

Sara Wojciechowski,Pulak Tripathi,Tristan Bourdeau,Luis Acero,H. Leighton Grimes,Jonathan D. Katz,Fred D. Finkelman,David A. Hildeman

View Articletitled, Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination

Xiaoming Wu,Janet Stavnezer

View Articletitled, DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

Sheng Xiao,Nader Najafian,Jay Reddy,Monica Albin,Chen Zhu,Eric Jensen,Jaime Imitola,Thomas Korn,Ana C. Anderson,Zheng Zhang,Cristina Gutierrez,Thomas Moll,Raymond A. Sobel,Dale T. Umetsu,Hideo Yagita,Hisaya Akiba,Terry Strom,Mohamed H. Sayegh,Rosemarie H. DeKruyff,Samia J. Khoury,Vijay K. Kuchroo

View Articletitled, Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

Distinct roles for Syk and ZAP-70 during early thymocyte development

Emil H. Palacios,Arthur Weiss

View Articletitled, Distinct roles for Syk and ZAP-70 during early thymocyte development

Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination

Pauline Soulas-Sprauel,Gwenaël Le Guyader,Paola Rivera-Munoz,Vincent Abramowski,Christelle Olivier-Martin,Cécile Goujet-Zalc,Pierre Charneau,Jean-Pierre de Villartay

View Articletitled, Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination

Correction

Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells

Marta Serafini,Scott J. Dylla,Masayuki Oki,Yves Heremans,Jakub Tolar,Yuehua Jiang,Shannon M. Buckley,Beatriz Pelacho,Terry C. Burns,Sarah Frommer,Derrick J. Rossi,David Bryder,Angela Panoskaltsis-Mortari,Matthew J. O'Shaughnessy,Molly Nelson-Holte,Gabriel C. Fine,Irving L. Weissman,Bruce R. Blazar,Catherine M. Verfaillie

View Articletitled, Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells

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